Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 943-554-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to guideline. In compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Diethyldimethylcyclohex-2-en-1-one
- EC Number:
- 272-462-3
- EC Name:
- Diethyldimethylcyclohex-2-en-1-one
- Cas Number:
- 68845-36-3
- Molecular formula:
- C12H20O
- IUPAC Name:
- 2,3-diethyl-4,4-dimethylcyclohex-2-en-1-one
- Reference substance name:
- Azarbre
- IUPAC Name:
- Azarbre
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- Please note that although the substance is stated as the mono-constituent substance diethyldimethylcyclohex-2-en-1-one in the report, analytical data on the same batch shows that the test substance is in fact the multi-constituent substance Reaction mass of 3,5-diethyl-2,5-dimethyl-cyclohex-2-en-1-one and 3,5-diethyl-5,6-dimethylcyclohex-2-en-1-one .
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- other: Chicken
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- The eyes used in this assay were collected from c hickens obtained from a slaughterhouse (Etablissement Brun, 338 Etauliers, France) where they were killed for human consumption. Chicken age was generally 7 weeks old.
The eyes of the chickens were enucleated at Phycher.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 30uL of test item was applied
- Duration of treatment / exposure:
- The test item was applied for 10 seconds so that it covered the entire surface of the cornea evenly. It was then rinsed from the eye with 20mL of physiological saline at ambient templerature.
- Observation period (in vivo):
- Treated corneas were evaluated pretreatment and after treatment 30, 75, 120, 180 and 240 minutes (+/- 5 minutes).
- Number of animals or in vitro replicates:
- 3 enucleated chicken eyes
- Details on study design:
- Negative controls (physiological saline) and positive controls (5% Benzalkonium chloride) were included in this experiment.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- maximum mean total score (MMTS)
- Remarks:
- Corneal Opacity
- Basis:
- mean
- Score:
- ca. 1.3
- Remarks on result:
- other: Corresponds to ICE class II
- Irritation parameter:
- other: Mean score of fluorescein retention
- Basis:
- mean
- Score:
- ca. 0.7
- Remarks on result:
- other: Corresponds to ICE class II
- Irritation parameter:
- cornea opacity score
- Remarks:
- Maximal mean corneal swelling
- Basis:
- mean
- Time point:
- other: 240 minutes post-dose
- Score:
- ca. 12
- Remarks on result:
- other: Corresponds to ICE class II
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
The results obtained under the experimental conditions described, lead to the conclusion that Azarbre is not a corrosive / severe irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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