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EC number: 237-525-1 | CAS number: 13826-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance 3-Phenoxybenzylalcohol is expected to show acute toxicity effect by the oral route. And other available data indicates that the substance is not likley to exhibit acute toxicity by the inhalation & dermal route of exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from QSAR Toolbox Version 3.3
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: The prediction is done using QSAR Toolbox version 3.3
- Principles of method if other than guideline:
- The prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 369.803 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The median lethal dose (LD50) value of the test substance 3-Phenoxybenzyl alcohol in rats was estimated to be 1369.8034 mg/kg bw.
- Executive summary:
The acute toxicity of 3-Phenoxybenzyl alcohol by oral route was estimated using QSAR Toolboox version 3.3
The median lethal dose (LD50) value of the test substance 3-Phenoxybenzyl alcohol in rats was estimated to be 1369.8034 mg/kg bw. Considering the CLP Criteria for classification of the substance, it is concluded that 3-Phenoxybenzyl alcohol is classified for acute oral toxicity Category IV to rat.
Reference
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((((((("a" and ("b" and ( not "c") ) ) and ("d" and ( not "e") ) ) and ("f" and ( not "g") ) ) and "h" ) and ("i" and ( not "j") ) ) and ("k" and ( not "l") ) ) and "m" ) and ("n" and "o" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Benzyl Alcohols by Aquatic toxicity classification by ECOSAR
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Not possible to classify according to these rules by DPRA Cysteine peptide depletion
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as High reactive OR High reactive >> Activated haloarenes by DPRA Cysteine peptide depletion
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as No alert found by DNA binding by OASIS v.1.3
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as AN2 OR AN2 >> Michael-type addition on alpha, beta-unsaturated carbonyl compounds OR AN2 >> Michael-type addition on alpha, beta-unsaturated carbonyl compounds >> Four- and Five-Membered Lactones OR SN2 OR SN2 >> Alkylation, ring opening SN2 reaction OR SN2 >> Alkylation, ring opening SN2 reaction >> Four- and Five-Membered Lactones by DNA binding by OASIS v.1.3
Domain logical expression index: "f"
Referential boundary: The target chemical should be classified as No alert found by Protein binding by OASIS v1.3
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as Nucleophilic addition OR Nucleophilic addition >> Addition to carbon-hetero double bonds OR Nucleophilic addition >> Addition to carbon-hetero double bonds >> Ketones by Protein binding by OASIS v1.3
Domain logical expression index: "h"
Referential boundary: The target chemical should be classified as Bioavailable by Lipinski Rule Oasis ONLY
Domain logical expression index: "i"
Referential boundary: The target chemical should be classified as Not categorized by Repeated dose (HESS)
Domain logical expression index: "j"
Referential boundary: The target chemical should be classified as Thiocarbamates/Sulfides (Hepatotoxicity) No rank by Repeated dose (HESS)
Domain logical expression index: "k"
Referential boundary: The target chemical should be classified as Non binder, without OH or NH2 group by Estrogen Receptor Binding
Domain logical expression index: "l"
Referential boundary: The target chemical should be classified as Non binder, impaired OH or NH2 group OR Non binder, non cyclic structure OR Strong binder, OH group by Estrogen Receptor Binding
Domain logical expression index: "m"
Referential boundary: The target chemical should be classified as Discrete chemical by Substance Type ONLY
Domain logical expression index: "n"
Parametric boundary:The target chemical should have a value of log Kow which is >= 2.31
Domain logical expression index: "o"
Parametric boundary:The target chemical should have a value of log Kow which is <= 3.45
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 658 mg/kg bw
- Quality of whole database:
- The predicted data is K2 level obtained from the QSAR 3.3 prediction results.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from online Chemical Repository Database
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- To observed acute inhalation toxicity given Inhalation exposure of rats for 1 hour to an aerosol and vapor atmosphere of 3 Phenoxybenzyl Alcohol at a concentration of 2.0 mg/l.
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Species:
- rat
- Strain:
- other: Charles River CD rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: the Ethyl Corporation, Ferndale,Michigan
- Age at study initiation: No data available
- Weight at study initiation:
Male rats :200 to 254 grams
Females rats: 200 to 220 grams
- Fasting period before study: No data available
- Housing: The rats were housed individually in wire-mesh cages and were kept throughout the pre- and post exposure periods in a temperature and humidity controlled room in accordance with standards outlined in the "Guide For the Care and Use of Laboratory Animals; DREW No. (N.LH. 74-23) 1974".
- Diet (e.g. ad libitum): Purina Laboratory Chow(ad libitum)
- Water (e.g. ad libitum): Water ( ad libitum)
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no temperature mention , only temperature control room given
- Humidity (%):no humidity mention , only humidity control room given
- Air changes (per hr):Not data available
- Photoperiod (hrs dark / hrs light): Not data available
IN-LIFE DATES: From: To: Not data available - Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- No data available
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 2 mg/l
- No. of animals per sex per dose:
- 5 male/ 5 female
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 48 hours
- Frequency of observations and weighing:
Frequency of observations: immediately following the 1 hour exposure period and twice daily after for 48 hours.
Frequency of weighing: Individual body weights were recorded prior to the 1 hour exposure and at 24 and 48 hours in order to detect any latent effects following the exposure.
- Necropsy of survivors performed: No necropsy was conducted because all of the rats survived the exposure and observation period.
- Other examinations performed: clinical signs, body weight
- other: The vapors and aerosols of the compound were generated by metering the liquid at the rate of 0.0494 ml/min with a Harvard® Infusion Pump into a positive pressure atomizer located near the chamber air inlet at the top of the exposure chamber. The "metered" concentration of the compound (2.0 mg/I) in the chamber atmosphere was calculated from the ratio of the rate of liquid dissemination (55.3 mg/min*) to the rate of total chamber airflow (27 l/min). The total chamber airflow represents the volume of air ejected from the atomizer plus the volume of make-up air. - Statistics:
- No data available
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 2 other: mg/l
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- None of the rats died in the experiment
- Clinical signs:
- other: The immediate response of the rats to the experimental atmosphere was an increase of activity in preening. After several minutes of exposure, this activity decreased. The rats appeared normal during the experimental period.
- Body weight:
- Details given in table below
- Gross pathology:
- No necropsy was conducted because all of the rats survived the exposure and observation period and were sacrificed and discarded.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LC0 value for the Charles River CD rat for 3-Phenoxybenzylalcohol (CAS No :13826-35-2) was found to be > 2 mg/l.
- Executive summary:
Acute inhalation study was performed on Charles River CD rats at 2 mg/l concentration. 5 male of weight from 200 to 254 grams and 5 female from 200 to 220 grams were used. The rats were housed individually in wire-mesh cages and were kept throughout the pre- and post-exposure periods in a temperature and humidity controlled room in accordance with standards outlined in the "Guide For the Care and Use of Laboratory Animals; DREW No. (N.LH. 74-23) 1974".
During exposure, the rats were caged individually in compartmented,Wire-mesh exposure cages. The cages were placed in a 160- liter cubical. Stainless steel and glass chamber. Constant chamber airflow was maintained by means of a rotary centrifugal air pump located at the exhaust side of the chamber. The chamber exhaust was filtered with an activated charcoal filter and a Cambridge Absolute filter before being discharged outside of the laboratory.
Observations for pharmacotoxic signs and mortality were made during and immediately following the 1 hour exposure period and twice daily thereafter for 48 hours.
None of the rats died in the experiment. No necropsy was conducted because all of the rats survived the exposure and observation period and were sacrificed and discarded.
Therefore, the LC0 value of 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) for Charles River CD rat was found to be >than 2 mg/l.
Reference
Body weight gain appeared normal during the 48 hour observation period
Individual Body Weights, Grams |
||||
Group, Rat No. |
Sex |
Pre-exposure |
Post-exposure (Days) |
|
2.0 mg/l |
|
|
|
|
16770 |
M |
205 |
214 |
228 |
16771 |
M |
254 |
260 |
270 |
16772 |
M |
200 |
208 |
222 |
16773 |
M |
203 |
211 |
212 |
16774 |
M |
225 |
244 |
252 |
16775 |
F |
220 |
226 |
232 |
16776 |
F |
210 |
212 |
212 |
16777 |
F |
208 |
215 |
220 |
16778 |
F |
200 |
208 |
214 |
16779 |
F |
218 |
232 |
233 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Value:
- 2 mg/m³ air
- Quality of whole database:
- The data is K4 level as the data has been obtained from the experimental study results.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from online Chemical Repository Database
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Acute Dermal Toxicity (LD50) Study in the Albino Rabbit assess for 14 days.
- GLP compliance:
- not specified
- Test type:
- other: Acute toxic class method
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kuiper's Rabbit Ranch, Gary, Indiana
- Age at study initiation: No data available
- Weight at study initiation: 2318 to 2925 grams
- Fasting period before study: No data available
- Housing: housed in hanging wire-mesh cages in temperature and humidity controlled quarters
- Diet (e.g. ad libitum): Purina Rabbit Chow(ad libitum)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): temperature controlled quarters(°C not mention)
- Humidity (%): humidity controlled quarters (% not mention)
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available - Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- MAXIMUM DOSE VOLUME APPLIED: 20000 mg/kg.
- Doses:
- 2500, 5000, 10000 and 20000 mg/kg.
- No. of animals per sex per dose:
- 8 male and 8 female
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Frequency: They were observed at 24 hours and daily thereafter for a total of 14 days for pharmacotoxic signs and dermal irritation
Weighing: Body weights were measured initially and at 7 and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: body weight, gross necropsy. - Statistics:
- No data available
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 10 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 6 702 - 14 921
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 10 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 5 000 - 20 000
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 10 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 5 000 - 20 000
- Other findings:
- Pharmacotoxic signs were observed during the 14-day observation period as hypo activity, decrease limb tone, ataxia, dehydration, emaciation etc.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD 50 value for the New Zealand white rabbits by 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) was found to be 10000 mg/kg.
- Executive summary:
Acute toxicity test (Dermal) inNew Zealand white rabbits by 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) was performed.
8 Male and 8 female animals were used for the study at 2500, 5000, 10000 and 20000 mg/kg.They were individually housed in hanging wire-mesh cages in temperature and humidity controlled quarters.The rabbits weighed from 2318 to 2925 grams at the beginning of the study.Body weights were measured initially and at 7 and 14 days.They were maintained in accordance with the recommendations contained in H.E.W. Publication No. 74-23 (N.L.H.) entitled "Guide for the Care and Use of Laboratory Animals.
The hair was removed from the back of each rabbit. The skin of one male and one female in each group was abraded with a scalpel blade.The test material was applied once only to the backs of the rabbits. The area wrapped with gauze bandaging and occluded with Saran Wrap and observed for 14 days. Gross necropsy was done if some rabbits were died during 14 days and at the end of 14 days.
From the above study and observations, the LD 50 value for the New Zealand white rabbits by 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) was found to be 10000 mg/kg.
Reference
Mortality:
Dosage level(mg/kg) |
Total Mortalities |
||
Male |
Female |
Total |
|
2500 |
0/2 |
0/2 |
0/4 |
5000 |
0/2 |
0/2 |
0/4 |
10000 |
1/2 |
1/2 |
2/4 |
20000 |
2/2 |
2/2 |
4/4 |
Clinical signs:
Days |
Erythema |
Edema |
Atonia |
Desquamation |
|||||||||
None |
Very slight |
slight |
moderate |
None |
Very slight |
slight |
None |
Very slight |
slight |
None |
Very slight |
slight |
|
1-3 |
|
|
2/4 |
2/4 |
2/4 |
|
2/4 |
4/4 |
|
|
4/4 |
|
|
4* |
|
|
3/3 |
|
|
2/3 |
1/3 |
1/3 |
|
2/3 |
3/3 |
|
|
5 |
1/3 |
|
2/3 |
|
2/3 |
|
1/3 |
1/3 |
|
2/3 |
3/3 |
|
|
6** |
1/2 |
|
1/2 |
|
2/2 |
|
|
1/2 |
|
1/2 |
1/2 |
|
1/2 |
7 |
1/2 |
1/2 |
|
|
2/2 |
|
|
|
1/2 |
1/2 |
|
|
2/2 |
8 |
2/2 |
|
|
|
2/2 |
|
|
1/2 |
|
1/2 |
|
|
2/2 |
9 |
2/2 |
|
|
|
2/2 |
|
|
1/2 |
|
1/2 |
|
1/2 |
1/2 |
10 |
2/2 |
|
|
|
2/2 |
|
|
1/2 |
1/2 |
|
|
1/2 |
1/2 |
11-14 |
2/2 |
|
|
|
2/2 |
|
|
2/2 |
|
|
|
|
2/2 |
*1 of 4 rabbits dead. **2 of 4 rabbits dead. |
|||||||||||||
|
Body weight:
The following body weights were obtained during the 14-day observation period:
Dosage level(mg/kg) |
Individual Rabbit no. |
Sex |
Control Weight |
7 day weights |
14 day weights |
10000 |
31683 |
Male |
2642 |
2050 |
2427 |
|
31685 |
Male |
2583 |
Died |
Died |
|
31710 |
Female |
2731 |
2363 |
2612 |
|
31714 |
Female |
2768 |
Died |
Died |
Gross pathology:
Rabbits which were scarified following 14 days of observations.
Number Exhibiting Sign/Number necropsied
Dosage Level (mg/kg)
|
2500 |
5000 |
10000 |
|||
Male |
Female |
Male |
Female |
Male |
Female |
|
No gross lesions |
2/2 |
1/2 |
2/2 |
1/2 |
1/1 |
1/1 |
Stomach, green fluid contents |
|
1/2 |
|
|
|
|
Stomach mucosa, dark red foci |
|
1/2 |
|
|
|
|
Spleen, pale coloration |
|
|
|
1/2 |
|
|
Sub-lumbar region, two areas of necrotic fat |
|
1/2 |
|
|
|
|
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 10 000 mg/kg bw
- Quality of whole database:
- The data is K4 level as the data has been obtained from the experimental study results.
Additional information
Acute toxicity: oral:
The acute toxicity of 3-Phenoxybenzyl alcohol by oral route was estimated using QSAR Toolboox version 3.3The median lethal dose (LD50) value of the test substance 3-Phenoxybenzyl alcohol in rats was estimated to be 1369.8034 mg/kg bw. Considering the CLP Criteria for classification of the substance, it is concluded that 3-Phenoxybenzyl alcohol is classified for acute oral toxicity Category IV to rat.
Acute toxicity: inhalation:
Acute inhalation study was performed onCharles River CD rats at 2 mg/l concentration. 5 male of weight from 200 to 254 grams and 5 female from 200 to 220 grams were used. The rats were housed individually in wire-mesh cages and were kept throughout the pre- and post-exposure periods in a temperature and humidity controlled room in accordance with standards outlined in the "Guide For the Care and Use of Laboratory Animals; DREW No. (N.LH. 74-23) 1974".
During exposure, the rats were caged individually in compartmented,Wire-mesh exposure cages. The cages were placed in a 160- liter cubical. Stainless steel and glass chamber. Constant chamber airflow was maintained by means of a rotary centrifugal air pump located at the exhaust side of the chamber. The chamber exhaust was filtered with an activated charcoal filter and a Cambridge Absolute filter before being discharged outside of the laboratory.
Observations for pharmacotoxic signs and mortality were made during and immediately following the 1 hour exposure period and twice daily thereafter for 48 hours.
None of the rats died in the experiment. No necropsy was conducted because all of the rats survived the exposure and observation period and were sacrificed and discarded.
Therefore,the LC0 value of3-Phenoxybenzylalcohol (CAS No: 13826-35-2) for Charles River CD rat was found to be >than 2 mg/l.
Acute toxicity: dermal:
Acute toxicity test (Dermal) inNew Zealand white rabbits by 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) was performed.
8 Male and 8 female animals were used for the study at 2500, 5000, 10000 and 20000 mg/kg.They were individually housed in hanging wire-mesh cages in temperature and humidity controlled quarters.The rabbits weighed from 2318 to 2925 grams at the beginning of the study.Body weights were measured initially and at 7 and 14 days.They were maintained in accordance with the recommendations contained in H.E.W. Publication No. 74-23 (N.L.H.) entitled "Guide for the Care and Use of Laboratory Animals.
The hair was removed from the back of each rabbit. The skin of one male and one female in each group was abraded with a scalpel blade.The test material was applied once only to the backs of the rabbits. The area wrapped with gauze bandaging and occluded with Saran Wrap and observed for 14 days. Gross necropsy was done if some rabbits were died during 14 days and at the end of 14 days.
From the above study and observations, the LD 50 value for the New Zealand white rabbits by 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) was found to be 10000 mg/kg.
Justification for selection of acute toxicity – oral endpoint
The median lethal dose (LD50) value of the test substance 3-Phenoxybenzyl alcohol in rats was estimated to be 1369.8034 mg/kg bw.
Justification for selection of acute toxicity – inhalation endpoint
The LC0 value for the Charles River CD rat for 3-Phenoxybenzylalcohol (CAS No :13826-35-2) was found to be > 2 mg/l.
Justification for selection of acute toxicity – dermal endpoint
The LD 50 value for the New Zealand white rabbits by 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) was found to be 10000 mg/kg.
Justification for classification or non-classification
Based upon the study results and available information, the substance 3-Phenoxybenzylalcohol is expected to show acute toxicity effect by the oral route in category 4 and thus will be considered for further classification. Available data indicates that the substance is not likely to exhibit acute toxicity by the inhalation and dermal route of exposure.
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