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Diss Factsheets
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EC number: 943-359-7 | CAS number: 2149581-44-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline Study with detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- MAEEBP
- IUPAC Name:
- MAEEBP
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): MAEEBP- Physical state: colourless liquid- Composition of test material, percentage of components: 4-methacryloyl diethoxy benzophenone 85 area%, impurities 4-hydroxybenzophenone <5%, 4-methacryloyl benzophenone <5%, polymethacrylate <5%- Lot/batch No.: 150301- Expiration date of the lot/batch: 31. Mar.. 2016- Storage condition of test material: fridge: 2-8°C, keep away from light and humidity
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)- Method: Corresponding amount added to dilution water and shaked vigorously for 23 hours. The resulting solution was filtrated through 0.45 µm nylon filters. The filter was rinsed with an aliquot of the respective water-accommodated fraction (WAF) before filling the test vessel. Then the water-accommodated fraction (WAF) was filtered in a glass beaker. This solution was transferred into the 4 replicates of the test vessels.- Dilution water specification: CaCl2*2H2O: 293.80 mg/LMgSO4*7H2O: 123.30 mg/LNaHCO3: 64.80 mg/LResulting hardness in mmol/L: 2.502Resulting hardness in mg CaCO3/L: 250
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM- Common name: Daphnia magna - Strain: STRAUS, Berlin- Source: Umweltbundesamt Berlin- Age at study initiation: <24 h- Method of breeding: Daphnia magna is bred in the LAUS GmbH throughout the year. The husbandry is performed similar to the method described in EN ISO 6341, following SOP 115 002 01 („Zucht und Hälterung von Daphnia magna STRAUS“), Version 12, valid from 02. Feb. 2015.- Feeding during test: no- Food type: unicellular green algae (Desmodesmus subspicatus)
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 250 mg CaCO3/L
- Test temperature:
- 19.0 – 21.0 °C
- pH:
- 7.6 - 7.7
- Dissolved oxygen:
- 7.5 - 8.9 mg/L
- Nominal and measured concentrations:
- 2.2, 4.6, 10, 22, 46 mg/L (nominal concentrations)Because of the limited solubility in test medium the correlation between nominal and measured concentration in the 3 highest concentrated treatments was weak. The correlation of the measured concentrations within the test concentrations was very good.The determination of the results was based on the geometric mean of the measured concentrations.
- Details on test conditions:
- TEST SYSTEM- Test vessel: Beakers, glass, nominal volume 50 mL- Fill volume: 20 mL- Aeration: After preparation, the dilution water was aerated- Renewal rate of test solution: 24 h- No. of organisms per vessel: 5- No. of vessels per concentration (replicates): 4- No. of vessels per control (replicates): 4TEST MEDIUM / WATER PARAMETERS- Source/preparation of dilution water: Deionised water with an enrichment of certain minerals (as demanded in the guidelines)- Intervals of water quality measurement: pH, the concentration of dissolved oxygen and the content of the test item in the test vessels were measured at the beginning and at the end of the test and at medium renewal in the old and the new test solutionOTHER TEST CONDITIONS- Adjustment of pH: no- Photoperiod: 16/8 hours
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 7.6 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: CI not determinable
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 14 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CI 13 - 17 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 4 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 7.9 g/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- - Results with reference substance valid? yes- 24h-EC50: 1.6 mg/L
- Reported statistics and error estimates:
- The estimation of the biological results was accomplished using the software ToxRat® Professional, version 3.2.
Any other information on results incl. tables
Immobility:
Nominal Concentration in mg/L | Immobility 24 hours | Immobility 48 hours | ||||||||
absolute | in % | absolute | in % | |||||||
Blank control | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
4.6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | 0 | 0 | 0 | 4 | 4 | 2 | 3 | 65 |
22 | 2 | 2 | 3 | 2 | 45 | 5 | 5 | 5 | 5 | 100 |
46 | 4 | 3 | 2 | 1 | 50 | 5 | 5 | 5 | 5 | 100 |
Measured Concentrations
Nominal | Measured Concentration | Measured Concentration | Measured Concentration | Measured Concentration t = 48 h | Geometric Mean |
mg/L | mg/L | mg/L | mg/L | mg/L | mg/L |
Blank control | < LOQ | < LOQ | < LOQ | < LOQ | -- |
2.2 | 1.96 | 2.03 | 2.15 | 2.18 | 2.08 |
4.6 | 3.94 | 4.01 | 4.00 | 4.08 | 4.01 |
10 | 7.95 | 8.09 | 7.60 | 7.90 | 7.88 |
22 | 12.72 | 13.43 | 11.99 | 12.46 | 12.64 |
46 | 14.45 | 14.35 | 14.19 | 14.87 | 14.46 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The short term toxicity of MAEEBP against Daphnia magna STRAUS was tested according to OECD 202 resp. EU C.2. The 48 h-EC50 value, based on the geometric mean of the measured concentrations, was determined to be 7.6 mg/L.
- Executive summary:
The short term toxicity of MAEEBP against Daphnia magna STRAUS was tested according to OECD 202 resp. EU C.2. For each test concentration, 20 Daphnia were exposed to the test item (46 / 22 / 10 / 4.6 / 2.2 mg) for 48 hours in a semi static test system. After 24 and 48 hours, the immobilised Daphnia were counted. 3 concentrations showed toxicity between 65 and 100% immobilisation after 48 hours. None of the animals were immobilised in the control. Potassium dichromate K2Cr2O7(CAS No. 7778-50-9) was used as positive control in a current reference study.The 24h-EC50 value was determined as 1.6 mg/L, lying within the demanded range of 0.6 – 1.7 mg/L stated in the EU guideline.
The concentration of the test item in the test solutions was determined using HPLC measurement at the start and at the end of the test and at medium renewal after 24 hours. Because of the limited solubility in test medium the correlation between nominal and measured concentration was weak and the measured concentrations in the higher concentrated treatments were in a similar range. Therefore, the determination of the results was based on the geometric mean of the measured concentrations.
The following results were determined for the test item MAEEBP(species:Daphnia magna).
48h-NOEC = 4.0 mg/L
48h-LOEC = 7.9 mg/L
24h-EC50 = 14 mg/L
48h-EC50 = 7.6 mg/L
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