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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26-27 May 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- A distinct saturation limit, as to be determined according to EU A.6, could not be identified for the main constituent of the test substance. Analytical method for quantification: Quantitative 1H-NMR using an internal standard
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- A distinct saturation limit, as to be determined according to EU A.6, could not be identified for the main constituent of the test substance. Analytical method for quantification: Quantitative 1H-NMR using an internal standard
- Principles of method if other than guideline:
- Deviations: Due to extremely hydrophilic and hygroscopic nature of the test material, the experimental procedure could not be performed in full compliance to the guidelines. A distinct saturation limit, as to be determined according to EU A.6, could not be identified for the main constituent of the test substance.
Analytical method for quantification: Quantitative 1H-NMR using an internal standard - GLP compliance:
- no
- Type of method:
- flask method
Test material
- Details on test material:
- - Name of test material (as cited in study report): reaction mass of tetra (potassium and sodium) (2R, 3R)-2-hydroxy-3-(phosphonatooxy) succinate and tetra (potassium and sodium) (2S,3S)-2-hydroxy-3-(phosphonatooxy) succinate
- Lot/batch No.: 010-2065
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- > 10 g/L
- Temp.:
- 25 °C
- pH:
- 9 - 9.2
- Remarks on result:
- other: The substance and its main constituents are considered to be very soluble. The total substance dissolves in water up to at least 40% w/w (at 25 °C). The main constituents are soluble in water in amounts of at least 67% w/w at this temperature.
Any other information on results incl. tables
Test substance solubility:
Generally, the test item solubility was excellent and up to 40% w/w optically clear solutions were obtained. For concentrations of 50% and higher, small amounts of insoluble material remained at the bottom of the glass after equilibration for 24h at 25 °C.
Solubility of the main constituent:
The turbidity occuring at concentration exceeding 40% w/w was assumed to be attributed to small amounts of the impurities described (especially potassium sodium tartrate). The solubility limit of the main constituent was expected to exceed 40% w/w significantly. Therefore a highly concentrated specimen was additionally investigated, which showed the presence of insoluble impurities concerning the content of the main constituent in the dissolved fraction. Even in contact with small amounts of water, the test material was sufficiently hydrated to change its aggregate state from solid to liquid. For concentrations of 80% w/w and more of the test material, a highly viscous, syrupy to tacky oil, is formed. Hence, the 3 highest sample solutions prepared (60, 70, 80 % w/w) have been investigated using NMR. Insoluble material residues were removed by centrifugation at 13000 rpm for 40 minutes. Approx. 150 mg of the clear upper layer were analyzed by a quantitative 1H-NMR technique using the internal standard sodium acetate as approx. 1% w/w stock solution in deuterium oxide.
The 80% w/w solution was of very high viscosity (> 3000 mPa s). Higher concentrations of substance were difficult for investigation due to high viscosity and related solid-liquid phase separation problems.
Substance concentration 010-2065 (approx. 84% w/w of main constituents) |
60% |
70% |
80% |
Concentration of main constituents (%w/w) theor. |
50.70% |
59.15% |
67.60% |
Concentration of main constituents found (%w/w) |
50.45% |
59.63% |
68.03% |
Main constituents found/main constituents theor. (%) |
99.5% |
100.8% |
100.6% |
As it can be derived from the table above, the match of theoretical and actual concentrations is excellent. Deviations are in the range of an experimental accuracy (ca. 1%). The study was performed without adjustement of pH. The main constituent is considered to be present in a fully deprotonated state at this value.
The main constituent is exclusively present in a dissolved state. It does not contribute to the formation of insoluble parts. It is not possible to determine an upper solubility limit for concentrations significantly higher than 68% w/w of the main constituents what corresponds to 80% w/w of the test substance. It can be concluded that the test material in its entirety shows very good water solubility.
The substance itself and its main constituents are considered to be very soluble in water. The total substance dissolves clearly in water up to at least 40% w/w (at 25 °C). The main constituents of the substance are soluble in water in amounts of at least 67% w/w at this temperature.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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