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EC number: 203-837-1 | CAS number: 111-13-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Cycloalkanones. 7.' Hypocholesterolemic Activity of Aliphatic Compounds Related to 2,8-Dibenzylcyclooctanone
- Author:
- G. L. Carlson, I. H. Hall, and C. Piantadosi
- Year:
- 1 975
- Bibliographic source:
- Journal of Medicinal Chemistry, 1975, Vol. 18, No. 10 pp 1024-1026
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Principles of method if other than guideline:
- To evaluate the Antifertility Activities of test chemical in female CF1 mice.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 111-13-6
- IUPAC Name:
- 111-13-6
- Reference substance name:
- Octan-2-one
- EC Number:
- 203-837-1
- EC Name:
- Octan-2-one
- Cas Number:
- 111-13-7
- Molecular formula:
- C8H16O
- IUPAC Name:
- octan-2-one
- Test material form:
- liquid
- Details on test material:
- Name of test material: Octan-2-one
- Molecular formula: C8H16O
- Molecular weight: 128.21 g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material: 2-octanone
- IUPAC name: octan-2-one
- Molecular formula: C8H16O
- Molecular weight: 128.2134 g/mol
- Substance type: Organic
- Physical state: Liquid
- Impurities (identity and concentrations): No data available
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- - Source: Carworth Farms
- Diet (e.g. ad libitum):Purina lab chow, ad libitum
- Water (e.g. ad libitum):water ad libitium
Administration / exposure
- Route of administration:
- intraperitoneal
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 1 %
- Details on exposure:
- DOSAGE PREPARATION (if unusual): Test compound was suspended in 1% carboxymethylcellulose- H20 (1% CMC) and homogenized
VEHICLE
- Concentration in vehicle:50 mg/kg
- Amount of vehicle (if gavage): No data
- Justification for choice of vehicle: 1% carboxymethylcellulose- H20 (1% CMC)
- Lot/batch no. (if required):
- Purity: - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- approx 19.4(gestation days) days.
- Frequency of treatment:
- Daily
- Duration of test:
- approx 19.4(gestation days) days.
Doses / concentrations
- Dose / conc.:
- 50 mg/kg bw/day
- No. of animals per sex per dose:
- Total no of animals-78 females
0 mg/kg/day-62 female rats
50 mg/kg/day-8 female rats
Diethyl stilbestrol: -8 female rats - Control animals:
- yes, concurrent vehicle
- Details on study design:
- Diethyl stilbestrol was used as positive control.
- Statistics:
- Yes, Student's t test and standard deviation were measured
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- body weight and weight gain
- clinical signs
- other: No effect on Number of reabsorption sites and dead in utero per litter, viable foetuses per litter
Observed effects
Any other information on results incl. tables
Antifertility Activities of Aliphatic Analogs of test chemical in CF1 Mice
Sr no |
Compound |
N |
%pregnant |
% average no. of foetuses per littera |
% average no. of reabsorption sites per littera |
1 |
Control |
62 |
100 |
100±25 |
100±25 |
2 |
test chemical |
8 |
75 |
87 |
0 |
3 |
Diethyl stilbestrol |
8 |
0 |
0 |
0 |
aAverage number of foetuses for CF1 mice = 12 ±3 and average number of reabsorption = 0.48 ± 0.12 per litter.
These values are considered to be 100%.
Applicant's summary and conclusion
- Conclusions:
- NOAEL was considered to be 50 mg/kg bw /day for P and F1 generation when CF-1 female mice were treated with test chemical daily approx 19.4(gestation days) days.
- Executive summary:
In an antifertility activity study, CF-1 female mice were treated with test chemical in the concentration of 50 mg/kg in 1% carboxymethylcellulose- H20 (1% CMC) and homogenized and administrated daily by intraperitoneally. No toxic clinical sign and change in body weight were observed in treated female mice at 50 mg/kg as compared to control. In addition, no reproductive effect such as number of reabsorption sites, dead in utero per litter, percent pregnant and number of viable foetuses per litter as compare to control. Therefore, NOAEL was considered to be 50 mg/kg bw /day for P and F1 generation when CF-1 female mice were treated with test chemical daily.
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