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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publication, meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Pharmacology and Toxicology of Niobium Chloride
Author:
Haley T.J., Komesu N., and Raymond K.
Year:
1962
Bibliographic source:
Toxicology and Applied Pharmacology 4: 385-392

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Niobium pentachloride
EC Number:
233-059-8
EC Name:
Niobium pentachloride
Cas Number:
10026-12-7
Molecular formula:
Cl5Nb
IUPAC Name:
Niobium(V) chloride
Details on test material:
- Name of test material (as cited in study report): Niobium pentachloride
- Analytical purity: 99.5%

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
other: abraded and unabraded
Vehicle:
not specified
Controls:
no
Observation period:
24 and 72 hours, 7 and 14 days
Number of animals:
6
Details on study design:
The author mentioned in the publication, that the method of Draize et al. (1944) was used to study skin irritation in rabbits. Niobium pentachloride was directly applied to unabraded and abraded rabbit skin.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Remarks:
unabraded skin
Basis:
mean
Time point:
other: 24 h, 72 h
Score:
4
Reversibility:
not reversible
Irritation parameter:
edema score
Remarks:
unabraded skin
Basis:
mean
Time point:
other: 24 h, 72 h
Score:
4
Reversibility:
not reversible
Irritation parameter:
other: eschar 25-30 mm in diameter
Basis:
mean
Time point:
other: within 7 days
Reversibility:
not reversible
Remarks on result:
other: No healing occurred and animals were sacrificed at 14 days
Irritation parameter:
overall irritation score
Remarks:
on abraded skin
Basis:
mean
Time point:
other: 24 h, 72 h
Score:
8
Max. score:
8
Reversibility:
not reversible
Remarks on result:
other: within 7 days perforating ulcers 25-30 mm in diameter with penetration through the skin.
Irritant / corrosive response data:
Direct application of niobium pentachloride to unabraded rabbit skin produced an irritation index of 4 within 24 hours for both edema and erythema. These reactions were still present at 72 hours. An eschar 25-30 mm in diameter formed within 7 days with the loss of the skin in the area. Healing did not occur and the animals were sacrificed at 14 days. A severe reaction occurred on abraded skin and resulted in the maximum irritation index of 8 within 24 hours. No change was observed at 72 hours, and within 7 days perforating ulcers 25-30 mm in diameter developed with penetration through the skin to the underlying muscle layers. When healing did not occur at 14 days, the animals were sacrificed.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In an acute dermal irritation/corrosion study according to the method of Draize et al. (1944), the test item is considered to be corrosive to the skin.
Executive summary:
In a primary dermal irritation study according to the method of Draize et al., six rabbits were dermally exposed to niobium pentachloride. Animals were observed for 1, 3, 7 and 14 days. On unabraded skin severe erythema and edema were formed within 24 hours continuing to eschars with 24-30 mm in diameter within 7 days that did not heal until day 14. On abraded skin, a maximum irritation index (8/8) was formed within 24 hours. No change was observed at 72 hours and perforating ulcers of 25-30 mm diameter size developed with penetration through the skin to the underlying muscle layers within 7 days. Healing did not occur during the 14 days observation period. Based on these findings, the test item is considered to be corrosive to the skin.