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EC number: 204-129-5 | CAS number: 116-16-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity of Some Perhalogenated Acetones
- Author:
- Joseph F. Borzelleca, David Lester
- Year:
- 1 965
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACOLOGY 7, 592-597 (1965)
Materials and methods
- Principles of method if other than guideline:
- Adult, male 1 albino rats of the Wistar strain, averaging 150 g in weight were used for these studies. They were housed 5 to a cage at a room
temperature of 23 +/- 1 °C. The animals were fasted overnight (water ad libitum but no food) prior to dosing by stomach tube. Ten rats were dosed at each of 4 or 5 dosages of a compound, After dosing, the rats were fed a commercial chow ad libitum. They were kept under observation for 4
weeks following treatment and any death occurring within that time were included in calculation of the result.
The LD50 values were calculated by the minimum approximate chi-square normit method of Berkson (1955). - GLP compliance:
- not specified
- Test type:
- other: min. 4 doses tested
- Limit test:
- no
Test material
- Reference substance name:
- Hexachloroacetone
- EC Number:
- 204-129-5
- EC Name:
- Hexachloroacetone
- Cas Number:
- 116-16-5
- Molecular formula:
- C3Cl6O
- IUPAC Name:
- hexachloropropan-2-one
- Details on test material:
- Boiling point: 204 °C
Specific gravity: 1.73 (25°C)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Adult, male, albino rats of the Wistar strain, averaging 150 g in weight, were used for these studies. They were housed 5 to a cage at a room temperature of 23 +/- 1 °C. The animals were fasted overnight (water ad libitum but no food) prior to dosing by stomach tube. Ten rats were dosed at each of 4 or 5 dosages of a compound. After dosing, the rats were fed a commercial chow ad libitum. They were kept under observation for 4 weeks
following treatment and any deaths occurring within that time were included in calculation of the result.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The animals were fasted overnight (water ad libitum but no food) prior to dosing by stomach tube. Ten rats were dosed at each of 4 or 5 dosages of a compound, After dosing, the rats were fed a commercial chow ad libitum. They were kept under observation for 4
weeks following treatment and any death occurring within that time were included in calculation of the result. - Doses:
- only the result is included in the publication, no data about doses
- No. of animals per sex per dose:
- 10 male animals per dose
- Control animals:
- not specified
- Details on study design:
- The animals were fasted overnight (water ad libitum but no food) prior to dosing by stomach tube. Ten rats were dosed at each of 4 or 5 dosages of a compound, After dosing, the rats were fed a commercial chow ad libitum. They were kept under observation for 4
weeks following treatment and any death occurring within that time were included in calculation of the result. - Statistics:
- The LD50 values were calculated by the minimum approximate chi-square normit method of Berkson (1955).
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 370 - 1 730 mg/kg bw
- Based on:
- test mat.
- Mortality:
- LD50 = 1550 +/- 180 mg/kg bw (determined with 40-50 rats)
- Clinical signs:
- other: Moderate to severe central nervous system depression was noted following administration, and this persisted for several days. No other signs were discernible.
- Gross pathology:
- No abnormalities were evident on gross autopsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- LD50 = 1550 +/- 180 mg/kg bw (determined with 40-50 rats).
- Executive summary:
The acute LD50's of several perhalogenated acetones by oral routes are presented. The compounds were administered oraJly to rats. The LD50 of hexachloroacetone after oral administration was found to be 1550 +/- 180 mg/kg bw (determined with 40-50 rats). The compound was administrated orally. hexachloroacetone caused depression of the central nervous system, but, otherwise, no specific toxic signs were associated with lethal doses. Oral administration did not lead to pulmonary damage from any of these compounds.
The mechanism of the lethal action of the latter compounds is not apparent in these studies.
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