Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 205-271-0 | CAS number: 136-99-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- October 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study on analogue substance used. Method differing from current OECD guideline/EC method (longer application period, occlusive patch), prior to GLP. Limited reporting details available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Consumer Product Safety Commission 16 CFR Ch. II § 1500.41
- GLP compliance:
- no
- Remarks:
- Prior to GLP principles
Test material
- Reference substance name:
- Fatty acids, coco, reaction products with 2-[(2-aminoethyl)amino]ethanol
- EC Number:
- 267-058-9
- EC Name:
- Fatty acids, coco, reaction products with 2-[(2-aminoethyl)amino]ethanol
- Cas Number:
- 67784-90-1
- IUPAC Name:
- Fatty acids, coco, reaction products with 2-[(2-aminoethyl)amino]ethanol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: no data, albino rabbits
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Housing: animals immobilized in racks for a 24-h period during the application.
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved. One site left intact and one site was abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml per site
- Concentration (if solution): as is
VEHICLE
no vehicle - Duration of treatment / exposure:
- 24 hours
- Observation period:
- Observations at the end of the 24-hour contact period and again 48 hours later.
- Number of animals:
- 3 rabbits
- Details on study design:
- TEST SITE
- Area of exposure: no data
- % coverage: ca. 10%
- Type of wrap if used: webril patches over the treated area and the entire experimental area sealed with Blenderm surgical tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: 24 hours
SCORING SYSTEM: Draize scale
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24-72 hrs
- Score:
- 3.5
- Max. score:
- 4
- Reversibility:
- no data
- Remarks:
- (not assessed)
- Remarks on result:
- other: For intact skin sites
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24-72 hrs
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- no data
- Remarks:
- (not assessed)
- Remarks on result:
- other: For intact skin sites
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 5
- Max. score:
- 8
- Reversibility:
- no data
- Remarks:
- (not assessed)
- Remarks on result:
- other: (intact and abraded skin)
- Irritant / corrosive response data:
- Severe primary irritant.
- Other effects:
- no data.
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information
- Conclusions:
- Limited details available for interpretation according to current criteria, but severe effects were observed on intact skin sites.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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