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EC number: 617-589-0 | CAS number: 84592-32-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to EEC Directive 92/69, B.1 and "Acute Toxic Class Method (ATC Method)" by E.Schlede et all., Arch. Toxicol. 66: 455-470 (1992). Test conducted under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- other: Acute toxic class method (ATC Method) by E. Schlede, U. Mischke, R. Roll, D. Kayser: A national validation study of the acute-toxic-class method - an alternative to the LD50 test. Arch. Toxicol. 66: 455-470 (1992).
- Principles of method if other than guideline:
- Method: other: Directive 92/69/EEC, B.1
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- [(5-(4-hydroxy-2,6,6-trimethyl-3-oxo-1-cyclohexen-1-yl)-3-methyl-2,4-pentadienyl](triphenyl)phosphonium bromide
- EC Number:
- 617-589-0
- Cas Number:
- 84592-32-5
- Molecular formula:
- C33 H36 O2 P .Br
- IUPAC Name:
- [(5-(4-hydroxy-2,6,6-trimethyl-3-oxo-1-cyclohexen-1-yl)-3-methyl-2,4-pentadienyl](triphenyl)phosphonium bromide
- Details on test material:
- - name of test substance: ASTA-C15-Salz Krist.
- chemical name: [5-(4-Hydroxy-2,6,6-trimethyl-3-oxo-1-cyclohexen-1-yl)-3-methyl-2,4-pentadienyl]triphenylphosphoniumbromid
- substance number: 96/337
- batch number: 95/49-4B/Trommel 2
- CAS number: 84592-32-5
- degree of purity/content: 98 G/100 G (HPLC)
- date of manufacturing: 08-Nov-1995
- physical state/appearance: solid, crystalline, ochre
- storage conditions: room temperature, exclusion of light, moisture and oxygen (storage under nitrogen).
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach, FRG
- Age at study initiation: young adult animals
- Weight at study initiation: 150 - 300 g (+/- 20% of mean weight)
- Fasting period before study: at least 16 hours
- Housing: single housing in stainless steel wire mesh cages; sawdust in the waste trays.
- Diet (e.g. ad libitum): Kliba-Labordiaet, Klingentalmuehle AG, Kaiseraugst, Switzerland, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12 h/12 h
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 4 g/100 mL (for 200 mg/kg bw level) and 40 g/100 mL (for 2,000 mg/kg bw level).
- Amount of vehicle (if gavage): max. 5 mL
MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg bw
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: Based on physical and chemical characteristics of the test substance and the composition, no pronounced acute oral toxicity was expected. Therefore, o starting dose of 2,000 mg/kg bw was selected. - Doses:
- 200 and 2,000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Signs: several times on the day of administration and at least once each workday thereafter. Weighing before and on ce a week after application.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, ptathology
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 200 - 2 000 mg/kg bw
- Mortality:
- Males
No mortality at the 200 mg/kg bw dose level.
1/3 males was found dead after 5 h at the 2,000 mg/kg bw dose level.
Females
No mortality at the 200 mg/kg bw dose level.
3/3 males were found dead after 2 h at the 2,000 mg/kg bw dose level. - Gross pathology:
- Necropsy findings
Animals that died: 2,000 mg/kg bw
- Agonal congestive hyperemia: 3 females
- Stomach: contents watery (1 male); deposit of test substance, slight, yellow (2 females); deposit of test substance, moderate, yellow (1 female).
- Glandular stomach: deposition, yellow, moderate (1 male); erosion/ulcer, few. diameter up to 1 mm, black (1 female).
- small intestine: discoloration of contents, yellow (1 male)
Sacrificed animals
- organ without particular findings: 2,000 mg/kg bw (2 males); 200 mg/kg bw (3 females, 3 males).
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study the median lethal dose of ASTA-C15- Salz Krist. after oral application was found to be greater than 200 mg/kg bw and less or equal to 2,000 mg/kg bw. Thus, the test substance needs to be classified acute tox. Cat. 4 and R22, according to Regulation (EC) No. 1272/2008.
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