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Diss Factsheets
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EC number: 910-245-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- other: volunteer study
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, adapted to human conditions. No information on purity of test substance.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Reference Type:
- secondary source
- Title:
- Soluble Silicates. CAS No. 1344-09-8, 6834-92-0, 10213-79-3, 13517-24-3 and 1312-76-1.
- Author:
- OECD SIDS
- Year:
- 2 004
- Bibliographic source:
- SIDS Initial Assessment Report for SIAM 18 Paris, France 20-23 April, 2004
Materials and methods
- Principles of method if other than guideline:
- COLIPA open cutaneous test
- GLP compliance:
- yes
- Remarks:
- Henkel KGaA Dermatologie
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- SOURCE: Henkel KGaA
PURITY: Not reported
IMPURITY/ADDITIVE/ETC.: Not reported
ANY OTHER INFORMATION: The test substance is a Natronwasserglas 37/40, a silicate solution of 34.9 wt% and a molar ratio 3.45.
Constituent 1
Test animals
- Species:
- human
Test system
- Type of coverage:
- open
- Vehicle:
- water
- Amount / concentration applied:
- Concentration: 34.9 other: wt%
application of 5, 10, 50% aqueous solutions and undiluted - Duration of treatment / exposure:
- 30 minute(s), the test substance was reapplied with a glass stick every 30 seconds. The test area on the inner lower arm was 3 cm2. After 30 minutes, the test area was rinsed with water and dried.
- Number of animals:
- 20 volunteers (10 male and 10 female)
- Details on study design:
- The adverse skin effects were scored for erythema and oedema until 30 minutes after the last application. The range ran from 0 (no reaction) to 4 (very strong redness spreading outside the test site and/or very strong oedema >2 mm). In addition the subjects were questioned to assess the occurrence of burning sensation, itching, pain, heat, cold.
Results and discussion
Any other information on results incl. tables
Clinical signs:
Exposure to undiluted sodium silicate solution did
not cause any irritation. It rapidly hardened on the skin,
forming a wax-like coating. The 50% aqueous dilution caused
slight redness (barely perceptible erythema) in 3/20
volunteers 21-25 minutes after the exposure started, and
lasted 15-19 minutes. The 10% aqueous dilution caused slight
redness (barely perceptible erythema) in 2/20 volunteers 21and 25 minutes after the exposure started, and lasted 19 and
15 minutes, respectively. Exposure to 5% dilution
resulted in slight redness (barely perceptible erythema) in
2/20 volunteers, which started 25 and 21 minutes after the
first exposure and lasted 15 and 19 minutes in total,
respectively. A third volunteer had a slight itch that
started right after the exposure ended, and lasted 30
minutes. All the adverse effects were reversible.
Under non-occlusive conditions the 5, 10 and 50% aqueous
dilutions of the sodium silicate solution caused slight irritation
(barely perceptible erythema). The undiluted sodium silicate solution
did not cause irritation.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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