Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: expert statement
Adequacy of study:
key study
Study period:
February 2007
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Theoretical assessment taking all currrently available relevant information into account, based on ECB EU Technical Guidance Document on Risk Assessment, 2003 (TGD)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report date:
2007

Materials and methods

Objective of study:
other: Assessment of toxicokinetic behaviour
Test guideline
Qualifier:
according to guideline
Guideline:
other: ECB EU Technical Guidance Document on Risk Assessment, 2003 (TGD)
GLP compliance:
no

Results and discussion

Main ADME results
Type:
absorption
Results:
For risk assessment purposes, 10% is used for oral and dermal absorption, 100% for inhalation absorption.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): other: For risk assessment purposes, 10% is used for oral and dermal absorption, 100% for inhalation absorption; Low bioaccumulation potential based on theoretical assessment.
MDI/CHA has a low bioaccumulation potential based on theoretical assessment.