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EC number: 500-109-8 | CAS number: 43011-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 2015-September 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Benzene-1,2,4-tricarboxylic acid 1,2-anhydride, oligomeric reaction products with ethane- l,2-diol
- EC Number:
- 500-109-8
- EC Name:
- Benzene-1,2,4-tricarboxylic acid 1,2-anhydride, oligomeric reaction products with ethane- l,2-diol
- Cas Number:
- 43011-20-7
- IUPAC Name:
- Benzene-1,2,4-tricarboxylic acid 1,2-anhydride, oligomeric reaction products with ethane- l,2-diol
- Reference substance name:
- BECKOPOX™ EH 694
- IUPAC Name:
- BECKOPOX™ EH 694
- Test material form:
- solid: crystalline
- Details on test material:
- Test Item: BECKOPOX™ EH 694
Lot Number: 310044522
CAS Number: 43011-20-7
Manufacturer: Allnex Italy
Appearance: Pale Granules
Composition: 2-{[(1,3-dioxo-1,3-dihydro-2-benzofuran-5-yl)carbonyl]oxy}ethyl 1,3-dioxo-1,3-dihydro-2-bezofuran-5-carboxylate
Expiry Date- 05.11.2015
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Source: Velaz Prague, Czech Republic.
6 females, 8-12 weeks, non-pregnant and nulliparous.
Acclimation for 5 days.
The animals were housed in plastic cages suspended on stainless steel racks, up to 3 animals per cage, with Lignocel S3/4 bedding (Lufa-ITL GmbH, Germany). Room temperature was 22 +/- 2 degrees C, relative humidity was 55 +/1 10%., 12/12 h light/dark phase.
A laboratory food Altromin (Altromin Spezialfutter GmbH, Germany) was offered in recommended doses each day approximately at the same time
The animals received tap water fit for human consumption. Supply of drinking water was unlimited.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- The test item was administered initally to 3 animals in a single dose by gavage using a metal stomach tube. Animals were fasted prior to dosing (food but not water was withheld overnight). Following the period of fasting, the animals were weighed and the test item administered. After the test item had been administered, food was withheld for an additional 3-4 hours. After a 24-hour observation period of the first dosed group showed no mortality, a second group of 3 animals were treated with the same dose.
- Doses:
- A limit dose of 2000 mg/kg was used as a starting dose.
- No. of animals per sex per dose:
- One group of 3 females was dosed at 2000 mg/kg. When test item mortality was not observed, another 3 females were treated at the same dose.
- Control animals:
- no
- Details on study design:
- Animals were observed individually immediately after administration of the test item and then 0.5, 1, 2 and 4 h later. Each animal was inspected daily for the next 14 days for changes in the following systems: skin and fur, eyes and mucous membranes, respiratory and circulatory, autonomic and central nervous systems, and somatomotor activity and behaviour patterns. Attention was directed to observations of tremors, convulsions, salivation, diarrhoea, lethary, sleep and coma. Body weights of animals were determined shortly before the the test item was administered and weekly thereafter. Weight differences after the first and second weeks were calculated and recorded.
All animals were subjected to a gross necropsy, including careful examination of the external surface of the body, all orifices, and cranial, thoracic and abdominal cavities and their contents. All gross pathological changes were recorded for each animal.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no adverse effects or mortality observed in any animal
- Mortality:
- No mortality was observed during the study. 6/6 females survived the limit dose of 2000 mg/kg.
- Clinical signs:
- No mortality was observed during the study. Animals lived through observation period without important visible signs of intoxication. Neither change of health nor negative reactions were registered.
- Body weight:
- Body weights of all animals increased during the 14-day study.
- Gross pathology:
- No macroscopic changes were noticed during necropsy.
Any other information on results incl. tables
BeckopoxTM EH 694 was tested in an OECD Guideline 423 test with a limit dose of 2000 mg/kg bw. No deaths or adverse effects occurred, and the LD50 is greater than 2000 mg/kg bw. It can be concluded that the substance is not classified according to Regulation EC No. 1272/2008.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- BECKOPOX™ EH 694 has a LD50 value greater than 2000 mg/kg, after single oral administration to Wistar rats.
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