Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 941-396-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Autoradiographic study on percutaneous absorption of several oils useful for cosmetics
- Author:
- Suzuki, K. et al.
- Year:
- 1 978
- Bibliographic source:
- J. Soc. Cosmet. Chem.,29, 265-282 (May 1978)
- Reference Type:
- secondary source
- Title:
- Final Report on the Safety Assessment of Trilaurin, Triarachidin, ....
- Author:
- Cosmetic Ingredient Review Panel
- Year:
- 2 001
- Bibliographic source:
- International Journal of Toxicology, 20(Suppl. 4):61-94, 2001
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Percutaneous absorption of C14-label trioelein was evaluated in male hairless mice , which recievd topical application of radiactive oil onto the skin. Animals were scrificed on different time points and fate of substance was evaluated by whole body autoradiography with hairless mice a.
- GLP compliance:
- no
- Remarks:
- prior to GLP
Test material
- Reference substance name:
- Glyceryl Trioleate
- IUPAC Name:
- Glyceryl Trioleate
- Details on test material:
- - Purity: labelled compounds were chemically and radiochemically pure as checked by thin layer chromatography using several different solvent systemsa nd scanningw ith a radiochromatograms cannerA loka TLC-2D.
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C
Test animals
- Species:
- mouse
- Strain:
- other: hr/hr
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean 25 g
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 1, 6, 24 and 48 h
- Doses:
- - Nominal doses:
- Actual doses: 0.01 mL with activity adjusted to approximatelyto 0.2/µCi/mg - No. of animals per group:
- no data
- Control animals:
- yes
- Remarks:
- other subszances
- Details on study design:
- TEST SITE
- Area of exposure: dorsal skin
- Preparation of test site: The hair on the dorsal region of animals was removed w ith a hair clipper and an electric shaver one day prior to topical application.
- Type of cover / wrap if used: 2.0 cm diameter Japanese papers backed w ith Lumirror© film covered with 3M Co.'s Micropore surgical tape
SAMPLE PREPARATION
- Preparation details: The mice were anesthetized with diethyl ether and immersed immediately in a dry ice acetone bath (-78 °C) at different intervals (1, 6, 24 and 48 h). Subsequently, whole body autoradiography was carried out according to the Ullberg method. Forty sagittal sections adhering to Scotch© Tape No. 810 (Sumitomo-3MC o., Ltd.) were prepared with a Jung type microtome from Yamatokoki Co., Ltd., in a freezing room (- l 5 °C). The sections were allowed to dry in that room, then brought into contact with Sakura X-ray film Industrial Type N (Konishiroku Photo Ind. Co., Ltd.), and exposed for 40 days. The film development was according to the usual procedure recommended by the manufacturer.
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
- Remarks:
- Slight erythema afetr 6 h, no effcets after 24 h
Any other information on results incl. tables
As determined by whole body autoradiography, 14C-Triolein did not penetrate into the body organs of mice. The oil remained localized at the application site at 48 hours post application.
Applicant's summary and conclusion
- Conclusions:
- No dermal absorption of 14C-labelled triolein was found after occlusive exposure for 48 in hairless mice.
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