Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-058-5 | CAS number: 2344-80-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Chloromethyltrimethylsilane
- EC Number:
- 219-058-5
- EC Name:
- Chloromethyltrimethylsilane
- Cas Number:
- 2344-80-1
- Molecular formula:
- C4H11ClSi
- IUPAC Name:
- (chloromethyl)trimethylsilane
- Test material form:
- other: colourless liquid
- Details on test material:
- Purity 99.8%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: HsdRccHan : WIST rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- HsdRccHan : WIST rats (Full-Barrier), Sex: females, non-pregnant, nulliparous.
Step 1: Body weight at the commencement of the study: 166 - 169 g;
Step 2: Body weight at the commencement of the study: 166 - 172 g;
Three female animals were used for each step.
The animals were derived from a controlled full barrier maintained breeding
system (SPF).
Source: Harlan Winkelmann GmbH, D-33178 Borchen.
According to Art. 9.2, No.7 of the German Act on Animal Welfare the
animals were bred for experimental purposes.
The animals were barrier maintained (semi-barrier) in an air conditioned
room
Temperature: 22 ± 3 QC
ReI. humidity: 55 ± 10%
Artificial light, sequence being 12 hours light, 12 hours dark
Air change: 10 x / hour
Feeding ad libitum, ssniff RIM-H, 10 mm V1534-000 complete diet for
rats/mice - maintenance, totally-pathogen-free (TPF)
Free access to tap water (drinking water, municipal residue control,
microbiol. controlled periodically)
The animals were kept in Macrolon cages on Lignocel bedding
Certificates of food, water and bedding are filed at BSL Bioservice
Adequate acclimatization period (at least 5 days).
The animals were marked for individual identification by tail painting.
Prior to the administration a detailed clinical observation was made of all
animals.
Prior to administration food was withheld from the test animals overnight.
Following the period of fasting the animals were weighed and the test item
was administered. Then the food cwas withheld for a further 3-4 hours.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- Aqua ad inj., B. Braun Melsungen AG, Lot 6153A195
- Details on oral exposure:
- In the first and second steps 2 gof the test item was dissolved with the
vehicle ad 10 mL to gain a concentration of 2000 mg/kg body weight.
The test substance was freshly mixed prior to administration and stirred
throughout dose administration to guarantee stability and homogeneity. The
vehicle was chosen due to its non-toxic characteristics.
The test item was administered in a single dose by gavage uSIng an
intubation cannula.
The test item was administered at a volume of 10 mL/kg body weight. - Doses:
- The starting dose (step 1) was selected to be 2000 mg/kg body weight. As
three of three animals survived, the second step was performed with the
same dose. According to the acute toxic class method regime no further
testing was required since no compound-related mortality was found in any
animals of step 2. - No. of animals per sex per dose:
- 3 male and 3 female animals, dose 2000 mg/kg bw
- Control animals:
- not specified
- Details on study design:
- The animals were observed for 14 days after dosing.
The animals were weighed prior to the administration and once a week A careful clinical examination was made several times on the day of dosing.
Part of this were at least three observations within the first four hours postdose.
The animals were weighed prior to the administration and once a week thereafter.
A careful clinical examination was made several times on the day of dosing.
Part of this were at least three observations within the first four hours postdose.
Animals were observed once a day thereafter.
Cageside observations included changes in the skin and fur, eyes and
mucous membranes. Also respiratory, circulatory, autonomic and central
nervous systems and somatomotor activity and behaviour pattern were
examined. Particular attention was directed to observations of tremor,
convulsions, salivation, diarrhoea, lethargy, sleep and coma.
At the end of the observation period the animals were sacrificed by an
overdosage ofpentobarbital.
All animals were subjected to gross necropsy. All gross pathological changes
were recorded. - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no
- Clinical signs:
- other: No treatment related effects were observed in any animals.
- Gross pathology:
- No special gross pathological changes were found in any animals.
- Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Considering the reported data of this toxicity test it can be stated that the test
item Chloromethyltrimethylsilane showed no oral toxic characteristics.
According to GHS (Globally Harmonized Classification System) the test
item Chloromethyltrimethylsilane was classified into Category 5 (LDso cutoff:
unclassified). - Executive summary:
The acute toxic class method was performed with the test item Chloromethyltrimethylsilane. A careful clinical examination was made several times on the day of dosing. Part of this were at least three observations within the first four hours postdose. Animals were observed once a day thereafter. In the first step the test item was given at a dose of 2000 mg/kg body weight to a group of 3 female rats (HsdRccHan : WIST) in a single exposure via oral gavage. No treatment related effects were observed in any animals of step 1. Therefore, the second step was performed with the same dosage in the same manner to a further group of 3 female rats (HsdRccHan : WIST). No treatment related effects were observed in any animals of step 2. At the end of the observation period the animals were sacrificed. Necropsy was carried out to record gross pathological changes. No treatment related effects were observed in any animals of steps 1 and 2. Beside acute injection ofblood vessels in the abdominal region, which is due to the euthanasia injection, no special gross pathological changes were found in any animals of steps 1 and 2. Throughout the 14-days observation period no weight loss was recorded in any animals (table 1). The weight gain was within the expected range. Therefore, according to OECD Guideline 423, a sufficient estimation of the acute oral toxicity of the test itenl is provided. Conclusions Considering the reported data of this toxicity test it can be stated that the test item Chloromethyltrimethylsilane showed no oral toxic characteristics. According to GHS (Globally Harmonized Classification System) the test item Chloromethyltrimethylsilane was classified into Category 5 (LDso cutoff: unclassified).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.