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EC number: 434-230-1 | CAS number: 144413-22-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 July 1998 - 20 August 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- starting dose was 200 mg/kg bw (recommended dose: 300 mg/kg bw)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): ARAKAWA KE-604
- Physical state: pale yellow blocks
- Analytical purity: no data
- Lot/batch No.: R61132
- Storage condition of test material: room temperature in the dark
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Ltd, Margate, Kent, UK
- Age at study initiation: 8 - 12 weeks
- Weight at study initiation: Males: 202-241 g, females: 202-220 g
- Fasting period before study: overnight before dosing and for approx. 3-4 h after dosing
- Housing: in groups up to three by sex in solid floor polypropylene cages with woodflakes bedding.
- Diet (e.g. ad libitum): Rat and Mouse Expanded Diet No. 1, Special Diets Services Ltd, Witham, Essex, UK
- Water (e.g. ad libitum): mains drinking water
- Acclimation period:at least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-23
- Humidity (%): 49-64
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
EXPERIMENTAL DATES: The study was performed between 28 July 1998 and 20 August 1998.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- VEHICLE
- Justification for choice of vehicle: Test substance was not water soluble
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose:
No toxicity data were available, therefore a starting dose of 200 mg/kg in females was used. - Doses:
- 200 mg/kg bw (starting dose) and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Animals were observed 0.5, 1, 2, 4 hours after dosing and once daily thereafter.
Body weights were recorded on Day 0 (day of dosing), 7 and 14, or at death.
- Necropsy of survivors performed: yes, all animals.
- Other examinations performed: clinical signs of systemic toxicity - Statistics:
- not required
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- One female rat dosed at 2000 mg/kg bw was found dead one day after dosing.
No mortalities occured at 200 mg/kg bw. - Clinical signs:
- Hunched posture, pilo-erection, decreased respiratory rate and laboured respiration were noted in the two surviving females dosed at 2000 mg/kg bw. No signs of systemic toxicity were noted in all other treated animals throughout the study.
- Body weight:
- All surviving animals showed the expected gain in bodyweight over the study period.
- Gross pathology:
- No abnormalitites were noted at necropsy of all animals killed at termination of the study.
In the female animal that died during the study, haemorrhagic lungs, dark liver, dark kidney and slight haemorrhage of the gastric mucosa were noted.
Any other information on results incl. tables
In an acute oral toxicity study (acute toxic class method according to OECD Guideline 423) fasted male and female (6/6) Sprague-Dawley CD rats were administered with 200 (starting dose) and 2000 mg/kg bw of the test substance ARAKAWA KE-604 in arachis oil.
No mortalities and no clinical signs of systemic toxicity occured at 200 mg/kg bw. One female rat dosed at 2000 mg/kg bw was found dead one day after dosing. Hunched posture, pilo-erection, decreased respiratory rate and laboured respiration were noted in the two surviving females dosed at 2000 mg/kg bw. No signs of systemic toxicity were noted in all other treated animals throughout the study. The acute oral LD(50) was calculated to be > 2000 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information No classification or labelling is required according to EU classification criteria. Criteria used for interpretation of results: EU
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