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Diss Factsheets
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EC number: 809-930-9 | CAS number: 1330-78-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 31, 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study, no specific methodology followed although documented report available.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- no guideline followed
- Guideline:
- other: For skin irritation, essentially the draize method is quoted.
- Deviations:
- yes
- Remarks:
- see below
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: 49 CFR 173.240 (a)(1) for dermal corrosion
- Deviations:
- yes
- Remarks:
- see below
- Principles of method if other than guideline:
- Dermal Irritation.
A group of albino New Zealand rabbits were used in this study. The test method was essentially that of Draize et .al.
Briefly paraphrased, it consisted of application of 0.5 ml (0.5 g) of the test material to clipped areas of intact and abraded skin. The abrasions were longitudinal epidermal incisions sufficiently deep to penetrate the stratum corneum, but not to deep as to destroy the integrity of the derma.
Applications were made under occiusive patches (2" x 2" gauze, covered by adhesive tape). Following application of the test material the entire trunk of each animal was covered with an impermeable occlusive wrapping. The availability of the test site to the animal is restricted by use of Elizabethan collars. The wrapping and test material were removed 24 hours following application. The sites were individually examined and scored separately for erythema and edema at 24 and 72 hours. The mean scores for 24 and 72 hour grading were averaged to determine final irritation indices.
Dermal Corrosion
A group of six (6) albino New Zealand rabbits in a weight range of 1.8 - 2.4 kg, were used in this study. The est method was essentially that of Draize et.al. Briefly paraphrased, it consisted of application of 0.5 ml (0.5 g) of the test material to clipped areas of intact skin. Applications were made under occlusive patches (2" x 2 gauze, covered by adhesive tape). Following application of the test material the entire trunk of each animal was covered with an impermeable occlusive wrapping. The animals were then immobilized.
The wrapping and test material were removed 4 hours following application. The sites were individually examined and scored separately for erythema and edema at 4 and 48 hours. The mean scores for 4 and 48 hour gradings were averaged to determine final irritation indices.
Corrosiveness seen at four and/or 48 hours alone indicates a corrosive material. Tissue destruction (corrosiveness) does not include merely sloughing of the epidermis, or erythema, edema or fissuring. - GLP compliance:
- no
Test material
- Reference substance name:
- Kronitex TCP (tricresyl phosphate)
- IUPAC Name:
- Kronitex TCP (tricresyl phosphate)
- Details on test material:
- - Name of test material (as cited in study report): Kreonitex TCP (tricresyl phosphate)
- Molecular formula (if other than submission substance): not applicable
- Molecular weight (if other than submission substance): not applicable
- Smiles notation (if other than submission substance): not applicable
- InChl (if other than submission substance): not applicable
- Structural formula attached as image file (if other than submission substance): see Fig. No
- Substance type: Not specified
- Physical state: Not specified
- Analytical purity: Not specified
- Impurities (identity and concentrations): Not specified
- Composition of test material, percentage of components: Not specified
- Isomers composition: Not specified
- Purity test date: Not specified
- Lot/batch No.: Not specified
- Expiration date of the lot/batch: Not specified
- Radiochemical purity (if radiolabelling): not applicable
- Specific activity (if radiolabelling): not applicable
- Locations of the label (if radiolabelling): not applicable
- Expiration date of radiochemical substance (if radiolabelling): not applicable
- Stability under test conditions: not specified
- Storage condition of test material: not specified
- Other:
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- All animals are fed and watered ad libitum; with Wayne animal feeds used exclusively. Animals are received from Summit View Farm, Belvidere, New
Jersey and are conditioned prior to use.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped, intact and abraded for dermal irritation test, clipped and intact for corrosion test
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml (0.5 g)
- Duration of treatment / exposure:
- 24 hours for irritation test, 4 hours for corrosion test.
- Observation period:
- 72 hours for irritation test, 48 hours for corrosion test
- Number of animals:
- 6 per test
- Details on study design:
- Primary Dermal Irritation: A group of albino New Zealand rabbits as indicated in the summary were used in this study. The tfst method was essentially that of Draize et .al. Briefly paraphrased, it consisted of application of 0.5 ml (0.5 g) of the test material to clipped areas of intact and abraded skin. The abrasions were longitudinal epidermal incisions sufficiently deep to penetrate the stratum corneum, but not so deep as to destroy the integrity of the derma. Applications were made under occlusive patches (2" x 2" gauze, covered by adhesive tape). Following application of the test material the entire trunk of each animal was covered with an impermeable occlusive wrapping. The availability of the test site to the animal is restricted by use of everted Elizabethan collars. The wrapping and test material were removed 24 hours following application. The sites were individually examined and scored separately for erythema and edema at 24 and 72 hours. The mean scores for 24 and 72 hour grading were averaged to determine final irritation indices.
Dermal Corrosion: A group of six (6) albino New Zealand rabbits in a weight range of 1.8 - 2.4 kg, were used in this study. The est method was essentially that of Draize et.al. Briefly paraphrased, it consisted of application of 0.5 ml (0.5 g) of the test material to clipped areas of intact skin. Applications were made under occlusive patches (2" x 2 gauze, covered by adhesive tape). Following application of the test material the entire trunk of each animal was covered with an impermeable occlusive wrapping. The animals were then immobilized. The wrapping and test material were removed 4 hours following application. The sites were individually examined and scored separately for erythema and edema at 4 and 48 hours. The mean scores for 4 and 48 hour gradings were averaged to determine final irritation indices. Corrosiveness seen at four and/or 48 hours alone indicates a corrosive material. Tissue destruction (corrosiveness) does not include merely sloughing of the epidermis, or erythema, edema or fissuring.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 0.5
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: for irritation test
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: for corrosion test
- Irritant / corrosive response data:
- Irritation test: Only minor scores (1) were seen in the study; these were fully reversible after 24 hours.
Corrosion test: No corrosion effects were noted within the study. - Other effects:
- None
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Kronitex TCP has the potential for slight dermal irritation. It is not a dermal corrosive.
- Executive summary:
Kronitex TCP was tested for primary dermal irritation and corrosiveness. Results indicate that has a potential for slight dermal irritation. It is not a dermal corrosive. No risk phrase or classification is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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