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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-338-0 | CAS number: 57-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
The calculated half life of monopropylene glycol in air is 0.83 days with an OH radical concentration of 1.5E06 OH/cm3 (Aopwin, 2000).
In accordance with column 2 of REACH Annex VIII, the hydrolysis test does not need to be conducted as the substance is readily biodegradable. Monopropylene glycol is expected to degrade rapidly in water from biological processes but is not expected to be significantly influenced by hydrolysis, oxidation, volatilization, bioconcentration, or adsorption to sediment (OECD SIDS, 2001).
The calculated half-life of monopropylene glycol in water is 2.3 years with an OH radical concentration of 10-17 mol/litre (Anbar, 1967). The indirect photolysis of monopropylene glycol by photochemically-produced hydroxy radicals is slow in water.
Under aerobic conditions, 106.8 % (O2 consumption), 81.7% (CO2 evolution) and 98.3% (DOC removal) biodegradation was found for 100 mg/l monopropylene glycol tested according to OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test) (West et al., 2007) and in another OECD 301 F study 81 -97% biodegradation was found for 84 mg/l monopropylene glycol tested under aerobic conditions (The Dow Chemical Company, 1999). In further assessment monopropylene glycol is considered ready biodegradable. In an OECD306 test (seawater), after 64 days 95.8 % biodegradation was observed (DOC removal) and 90.6% biodegradation was observed (CO2evolution)(West et al., 2007)
Significant biodegradation was found in a simulation test with natural seawater after 64 days (The Dow Chemical Company, 2004). When released into a soil environment propylene is expected to biodegrade (98% after 105 days) (The Dow Chemical Company, 1986).
Simulation studies with sediment are not available.
Based on the result of the octanol/water partition coefficient (Log Kow = -1.07) monopropylene glycol is not expected to significantly accumulate in aquatic organisms.
Based on the result of the octanol/water partition coefficient (Log Kow of -1.07) monopropylene glycol is expected to have a low potential for adsorption/desorption.
The calculated Henry's law constant at environmental relevant temperature is 0.0566 Pa.m3/mol using EUSES calculation (The European Union System for the Evaluation of Substances, 2008).
Volatility is not expected to be a significant fate process due to its low vapor pressure and high water solubility.
Based on the EPIWIN Level III Fugacity Model monopropylene glycol is expected to partition primarily to soil (48.1%) and water (48.8%). (OECD SIDS, 2001).
An over archiving review publication is available (West et al. (2014)) which discusses as a result of the variety of scenarios for environmental release, the potential hazards of and exposure associated with manufacture, transport and use/disposal of products containing or manufactured from monopropylene glycol.
Reference:
West, R., et al. (2014). The distribution, fate, and effects of propylene glycol substances in the environment. Reviews of environmental contamination and toxicology 232: 107-138.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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