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Diss Factsheets
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EC number: 204-442-7 | CAS number: 121-00-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance tert-butyl-4-methoxyphenol relatively do not show repeated dose toxicity by oral route.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 6W
- Frequency of treatment:
- Continuous
- Control animals:
- not specified
- Dose descriptor:
- LOEL
- Effect level:
- 63 000 mg/kg bw (total dose)
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Overall effects : Toxic Effects : Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- Critical effects observed:
- not specified
- Conclusions:
- The repeated dose toxicity LOEL (TDLo - Lowest published toxic dose) of tert-butyl-4-methoxyphenol was observed at a dose concentration of 63000 mg/kg bw (total dose) in a 6 weeks study period where the dosage of tert-butyl-4-methoxyphenol was continuously given to rats orally.This indicates that tert-butyl-4-methoxyphenol shall not exhibit toxic effect to rat by the oral route below the above mention dose.
- Executive summary:
The repeated dose toxicity LOEL (TDLo - Lowest published toxic dose) of tert-butyl-4-methoxyphenol was observed at a dose concentration of 63000 mg/kg bw (total dose) in a 6 weeks study period where the dosage of tert-butyl-4-methoxyphenol was continuously given to rats orally.This indicates that tert-butyl-4-methoxyphenol shall not exhibit toxic effect to rat by the oral route below the above mention dose.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 63 000 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from QSAR Toolbox version 3.2
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- not specified
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Dose descriptor:
- LOEL
- Effect level:
- 154.852 other: mg/kg bw/day
- Based on:
- test mat.
- Sex:
- not specified
- Critical effects observed:
- not specified
- Conclusions:
- Repeated dose toxicity LOEL (Lowest observed effect level) of tert-butyl-4-methoxyphenol to rat by the inhalative route was observed at dose concentration of 154.8519 mg/kg bw/day.
- Executive summary:
Repeated dose toxicity LOEL (Lowest observed effect level) of tert-butyl-4-methoxyphenol to rat by the inhalative route was observed at dose concentration of 154.8519 mg/kg bw/day.
Reference
The prediction was based on dataset comprised from the following descriptors: "effect LOEL"
Estimation method: Taking average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and "b" ) and ("c" and "d" ) )
Domain logical expression index: "a"
Similarity boundary:Target: C(C)(C)(C)c1c(O)ccc(OC)c1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Similarity boundary:Target: C(C)(C)(C)c1c(O)ccc(OC)c1
Threshold=60%,
Dice(Atom pairs)
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is >= 2.61
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is <= 4.2
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Species:
- rat
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Repeated dose toxicity: oral
The repeated dose toxicity LOEL (TDLo - Lowest published toxic dose) of tert-butyl-4-methoxyphenol was observed at a dose concentration of 63000 mg/kg bw (total dose) in a 6 weeks study period where the dosage of tert-butyl-4-methoxyphenol was continuously given to rats orally.This indicates that tert-butyl-4-methoxyphenol shall not exhibit toxic effect to rat by the oral route below the above mention dose.
Repeated dose toxicity: inhalation
Repeated dose toxicity LOEL (Lowest observed effect level) of tert-butyl-4-methoxyphenol to rat by the inhalative route was observed at dose concentration of 154.8519 mg/m3 air.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
LOEL value of tert-butyl-4-methoxyphenol observed was 63000 mg/kg bw/day therefore NOAEL value of tert-butyl-4-methoxyphenol is bound to be less than 63000 mg/kg bw/day.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.