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EC number: 236-102-9 | CAS number: 13162-05-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Aug. 21, 1981 to Sept. 7, 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 with acceptable restrictions (non-GLP, low number of rats).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- Annex: Inhalation Hazard Test
- Deviations:
- yes
- Remarks:
- only 6 animals instead of 10
- GLP compliance:
- no
- Test type:
- other: Inhalation Hazard Test
- Limit test:
- yes
Test material
- Reference substance name:
- N-vinylformamide
- EC Number:
- 236-102-9
- EC Name:
- N-vinylformamide
- Cas Number:
- 13162-05-5
- Molecular formula:
- C3H5NO
- IUPAC Name:
- N-vinylformamide
- Details on test material:
- - Analytical purity: 97.5%
- Impurities (identity): Formamide
- Physical state: liquid
- Storage condition of test material: refrigerator
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wiga, Sulzfeld, Germany
- Age at study initiation: 7-10 weeks
- Weight at study initiation: 180-250 g
- Housing: Wire mesh cage (Becker, D III), 3 animals/cage
- Diet: Herilan MRH of EGGERSMANN KG, Rinteln, Germany, in the form of pellets ad libitum
- Water: About 250 ml/cage tap water daily
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2°C
- Humidity (%): 55 +/- 5%
- Photoperiod (hrs dark / hrs light): 12 / 12 (6 .00 - 18 .00 h light, 18 .00 - 6 .00 h dark)
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other:
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
The test substance was filled to a height of 5 cm in a glass bottle (fritted glass flask, pore-size 90 - 150 µm, diameter 30 mm), and the net weight was determined. A stream of 200 l/h compressed air was supplied to the fritted glass flask containing the product, which had been placed in a water bath maintained at 20 +/- 1°C by a thermostat. The mixture of air and test substance generated in this way was passed through a glass distributor to 6 glass tubes in which 3 male and 3 female animals had been placed. The emerging mixtures of test substance and air were exhausted. After 30 min, the fritted glass flask was replaced by a new one filled with fresh test substance as described above. This generator was then used for the whole remaining time of the test.
TEST ATMOSPHERE
- Samples taken from breathing zone: no - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- Concentrations:
- Saturated vapour (The test substance consumed was determined by reweighing the fritted glass flasks).
- No. of animals per sex per dose:
- 3 males and 3 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Clinical signs of the animals were recorded daily.
- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- other: Inhalation Hazard Test
- Effect level:
- other: saturated vapor
- Exp. duration:
- 7 h
- Remarks on result:
- other: no mortality observed
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- ca. 380 mg/m³ air
- Exp. duration:
- 7 h
- Remarks on result:
- other: calculated using MW 71.08 and vapour pressure 0.13 hPa
- Mortality:
- No mortality observed
- Clinical signs:
- other: During exposure: attempts to escape, wiping of snouts After exposure: normal
- Body weight:
- Not determined
- Gross pathology:
- Nothing abnormal detected in the organs
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Conclusions:
- No mortality occurred in rats exposed for 7 h to a saturated vapour of the test substance.
- Executive summary:
The study is comparable to the inhalation hazard test described in the Annex of OECD Guideline 403 with acceptable restrictions (non-GLP, low number of rats).
Three male and 3 female rats were exposed for 7 h to a saturated vapour of the test substance. Clinical signs during exposure were attempts to escape and wiping of snouts. After exposure no clinical signs were observed. No mortalities occurred during the 14 days of post-exposure observation period. Nothing abnormal was detected in the organs at necropsy.
Conclusion: No mortality occurred in rats exposed for 7 h to a saturated vapour of the test substance.
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