Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 228-787-8 | CAS number: 6358-85-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- year of publication: 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism Studies of an Azo Dye and Pigment in the Hamster Based on Analysis of the Urine for Potentially Carcinogenic Aromatic Amine Metabolites
- Author:
- Nony CR, Bowman MC, Cairns T, Lowry LK, Tolos WP
- Year:
- 1 980
- Bibliographic source:
- Journal of Analytical Toxicology 4: 132-140
- Report date:
- 1980
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- investigation of metabolism after single oral application
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenylbutyramide]
- EC Number:
- 228-787-8
- EC Name:
- 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenylbutyramide]
- Cas Number:
- 6358-85-6
- Molecular formula:
- C32H26Cl2N6O4
- IUPAC Name:
- 2-[2-(3,3'-dichloro-4'-{2-[2-oxo-1-(phenylcarbamoyl)propyl]diazen-1-yl}-[1,1'-biphenyl]-4-yl)diazen-1-yl]-3-oxo-N-phenylbutanamide
- Test material form:
- not specified
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- hamster
- Strain:
- other: Syrian Golden
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: trioctanoin
- Duration and frequency of treatment / exposure:
- 192 hrs, single exposure
Doses / concentrations
- Dose / conc.:
- 100 mg/kg bw/day (actual dose received)
- Remarks:
- Doses / Concentrations:
100 mg/kg
- No. of animals per sex per dose / concentration:
- 3 males
- Control animals:
- no
Results and discussion
Main ADME results
- Type:
- excretion
- Results:
- no 3,3'-dichlorobenzidine, monoacetyldichlorobenzidine, diacetyldichlorobenzidine or alkali hydrolyzable conjugates detectable
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parameters
- Key result
- Test no.:
- #1
- Toxicokinetic parameters:
- other: no 3,3'-dichlorobenzidine, monoacetyldichlorobenzidine, diacetyldichlorobenzidine or alkali hydrolyzable conjugates were detectable in urine
Metabolite characterisation studies
- Metabolites identified:
- no
- Details on metabolites:
- None of the possible metabolites analysed for (3,3'-dichlorobenzidine, monoacetyldichlorobenzidine, diacetyldichlorobenzidine and alkali hydrolyzable conjugates) were detected in any of the urine samples.
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- no detected
Applicant's summary and conclusion
- Conclusions:
- Hamsters treated orally with the test item did not excrete 3,3'-dichlorobenzidine, monoacetyldichlorobenzidine, diacetyldichlorobenzidine or alkali hydrolyzable conjugates in the urine collected up to 192 hours after the end of the exposure period.
- Executive summary:
Male Syrian Golden Hamsters were applied a single dose of 100 mg test item per kg bw by gavage and urine was collected for up to 192 hours after exposure. No metabolites (3,3'-dichlorobenzidine, monoacetyldichlorobenzidine, diacetyldichlorobenzidine or alkali hydrolyzable conjugates) were detectable in urine by HPLC or EC-GC. Fecal analysis was not performed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.