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Diss Factsheets
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EC number: 500-457-0 | CAS number: 160901-19-9 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the category justification provided in the category object.
Data source
Materials and methods
Test material
- Reference substance name:
- Alcohols, C12-13, branched and linear, ethoxylated
- EC Number:
- 500-457-0
- EC Name:
- Alcohols, C12-13, branched and linear, ethoxylated
- Cas Number:
- 160901-19-9
- Molecular formula:
- not applicable; UVCB
- IUPAC Name:
- Alcohols, C12-13, branched and linear, ethoxylated
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 300 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Basis for effect level:
- clinical signs
Maternal abnormalities
- Key result
- Abnormalities:
- effects observed, treatment-related
- Localisation:
- other: clinical signs of systemic toxicity
Results (fetuses)
Effect levels (fetuses)
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 300 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: reduced pup weights as a secondary effect to systemic maternal toxicity
Fetal abnormalities
- Key result
- Abnormalities:
- effects observed, treatment-related
- Localisation:
- other: reduced pup weights as a secondary effect to systemic maternal toxicity
Overall developmental toxicity
- Key result
- Developmental effects observed:
- yes
- Lowest effective dose / conc.:
- 300 mg/kg bw/day (actual dose received)
- Treatment related:
- yes
- Relation to maternal toxicity:
- developmental effects as a secondary non-specific consequence of maternal toxicity effects
- Dose response relationship:
- yes
- Relevant for humans:
- no
Any other information on results incl. tables
For a detailed assessment of the developmental toxicity of the Alcohol Ethoxylates (AE) category, please refer to the category justification attached to the category object.
Applicant's summary and conclusion
- Conclusions:
- Applying read-across based on grouping of substances (category approach), reduced pup weights and a NOAEL for developmental toxicity of 300 mg/kg bw/day are predicted for the registered substance. Reduced pup weights are considered to be a secondary effect to systemic maternal toxicity.
- Executive summary:
The available data on developmental toxicity in the 'branched & linear' subgroup of the Alcohol Ethoxylates (AE) category indicate reduced pup weights for the registered substance. Reduced pup weights are considered to be a secondary effect to systemic maternal toxicity. As explained in the category justification, the differences in molecular structure and composition between the registered substance and the members of the 'branched & linear' subgroup of the AE category are unlikely to lead to differences with respect to developmental toxicity.
Pursuant to compliance check final decision for several branched & linear AE substances, prenatal developmental toxicity studies in a first (rat) and/or a second (rabbit) species according to OECD guideline 414 are currently ongoing. The NOAEL for developmental toxicity established for alcohols, C12-13, branched and linear, ethoxylated, < 2.5 EO (CAS No. 160901-19-9, EC No. 500-457-0) will be re-evaluated once the results of the OECD 414 studies conducted with other branched & linear AE substances are available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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