Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-500-4 | CAS number: 141-78-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Not a standard study. Original study report is not available and owners are not prepared to make it available. However, it is summarised in detail in the OECD SIAR and the criteria document for the UK occupational exposure standard and regarded as reliable by both the OECD and UK HSE, therefore it is regarded as reliable here.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Ethyl acetate SIDS initial assessment profile.
- Author:
- OECD
- Year:
- 2 004
- Bibliographic source:
- OECD SIAM 14, Paris, 2002
- Report date:
- 2002
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Reference Type:
- secondary source
- Title:
- Criteria document for ethyl acetate exposure limit
- Author:
- UK ACTS/WATCH committee
- Year:
- 2 001
- Bibliographic source:
- EH64 D113 (UK HMSO)
- Reference Type:
- secondary source
- Title:
- Recommendation from scientific expert group on occupational exposure limits for ethyl acetate
- Author:
- European Commission
- Year:
- 1 997
- Bibliographic source:
- SEG/SUM/1D October 1997
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- eye irritation
- respiratory irritation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The purpose of the study was to characterize the URT irritancy effects experienced from human volunteer exposure to ethyl acetate vapour, including the exposure-response relationship and the time course of the effects. The study was part of a larger project to develop and test out an irritancy questionnaire which was the method to assess the subjective effects experienced.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl acetate
- EC Number:
- 205-500-4
- EC Name:
- Ethyl acetate
- Cas Number:
- 141-78-6
- Molecular formula:
- C4H8O2
- IUPAC Name:
- ethyl acetate
- Details on test material:
- - Name of test material (as cited in study report): ethyl acetate
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 9 volunteers
- Ethical approval:
- confirmed and informed consent free of coercion received
- Route of exposure:
- inhalation
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
- Details on exposure:
- Concentrations used: 200, 400, 600, 800 and 1000 ppm.
Exposure duration: 200/400ppm: 4 hours. 600/800/1000ppm 15 minutes.
The vapour was generated by bubbling compressed air through glass vessels containing ethyl acetate at 25 degreesC.
The concentration of ethyl acetate in the exposure chamber was by two methods: infrared spectrometry analysis continuous sampling and gas chromatographic analysis (FID) every 30 minutes. - Examinations:
- Measurements included eye blink rates redness (both measured offline from video recordings taken during exposure.), and perceived irritancy/odour using a questionnaire. Full details of the questionnaire and results are recorded in the report. Symptoms recorded included pricking, itching, burning, dryness, watering, soreness, stinging of the eyes, nose, mouth and throat. Other symptoms recorded included runny, dry or blocked nose, sneezing, swollen glands and coughing (dry, tickly or other.)
- Medical treatment:
- not applicable.
Results and discussion
- Clinical signs:
- Exposure to 200ppm was clearly without effect. Exposure to 400ppm for 4 hours produced marginal subjective sensations of mild to medium eye soreness in 2 out of 6 individuals. Exposure to high levels (600-1000ppm) for short periods produced increasing subjective sensations, albeit only mild to medium in the eyes, nose and throat of some volunteers. No changes in eye redness were observed. There was a wide variation in blink rate between individuals and there was no correlation with exposure.
Applicant's summary and conclusion
- Executive summary:
The irritancy effects from exposure to ethyl acetate, the exposure-response relationship and the time course of the effects were studied in human volunteers. Exposure to 200ppm was clearly without effect. Exposure to 400ppm for 4 hours produced marginal subjective sensations of mild to medium eye soreness in 2 out of 6 individuals. Exposure to high levels (600-1000ppm) for short periods produced increasing subjective sensations, albeit only mild to medium in the eyes, nose and throat of some volunteers. No changes in eye redness were observed. There was a wide variation in blink rate between individuals and there was no correlation with exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.