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Diss Factsheets
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EC number: 204-506-4 | CAS number: 121-91-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-03-29 to 1990-04-01
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Proprietary study, similar to current OECD guidelines.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isophthalic acid
- EC Number:
- 204-506-4
- EC Name:
- Isophthalic acid
- Cas Number:
- 121-91-5
- Molecular formula:
- C8H6O4
- IUPAC Name:
- isophthalic acid
- Details on test material:
- - Name of test material (as cited in study report): isophthalic acid
- Physical state: White powder
- Storage condition of test material: Room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- The animals were New Zealand White rabbits (of either sex), purchased from Johnson Rabbit Ranch. Rabbits weighed approximately 2.0-3.5 kg on arrival. Rabbits were housed individually in stainless steel suspended cages. Each rabbit was given approximately 150 g of Purina Lab Rabbit Chow HF #5326. Reverse-osmosis purified water was provided ad libitum. Individuals were identified by metal ear tags. The temperature and relative humidity of the animal rooms was monitored, and fluorescent lighting was provided on a 12 hour light/dark cycle.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 g test material was applied undiluted to the back's of the rabbits. Individual doses were weighed onto aluminium foil.
- Duration of treatment / exposure:
- 4 hours exposure
- Observation period:
- 72 hours
- Number of animals:
- Three
- Details on study design:
- Rabbits were selected at random. Prior to study initiation, the backs of all candidate test animals were shaved and examined for abnormalities. Animals with significant skin abnormalities were not used in the study.
Approximately 24 hours prior to testing, fur from the trunk of the animals was clipped so that no less than 10% of the dorsal body surface area was available for application. A 0.5 g dose was applied, and the treated site covered by a 2.5 cm³ adhesive dressing (Coverlet). The entire midsection of the rabbit was wrapped in a lint-free cloth towel and secured by Elastoplast. All wrapping materials and adhesive dressings were removed after 4 hours, and the application site was rinsed with 0.9% saline and towel dried to remove excess test material.
All animals surviving to study termination were euthanised, necropsies were not performed.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not relevant
- Remarks on result:
- other: No signs of dermal irritation or corrosivity were seen in any rabbit during the study
- Irritant / corrosive response data:
- No signs of dermal irritation or corrosivity were seen in any rabbit during the study.
- Other effects:
- None documented
Any other information on results incl. tables
No signs of dermal irritation or corrosivity were seen in any rabbit during the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No signs of dermal irritation or corrosivity were observed in any rabbit during the study.
- Executive summary:
Isophthalic acid was applied undiluted for 4 hours to the shaved back of three New Zealand White rabbits at a concentration of 0.5g. All test sites were examined for signs of dermal irritation and corrosivity 30 - 60 minutes, 24, 48 and 72 hours following removal of the wrappings. The irritation score was 0.0/8.0 at all time points following unwrapping. The Primary Dermal Irritation Score was 0.0. No signs of dermal irritation or corrosivity were observed in any rabbit.
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