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EC number: 231-768-7 | CAS number: 7723-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1 April 1974 to 31 May 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study investigated the absorption, distribution and metabolism of orally administered radiolabelled white phosphorus
- GLP compliance:
- no
- Remarks:
- : older study
Test material
- Reference substance name:
- Phosphorus
- EC Number:
- 231-768-7
- EC Name:
- Phosphorus
- Cas Number:
- 7723-14-0
- Molecular formula:
- P
- IUPAC Name:
- phosphorus
- Test material form:
- solid
- Details on test material:
- Elemental phosphorus is often referred to as yellow phsophorus
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 32P-labeled white phosphorus
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Female Charles River CD rats were obtained from the Charles River Breeding Laboratories (Massachusetts). They were kept in air conditioned rooms (75±5°F) with relative humidity of 50±10%, and a photoperiod of 12 hours. They were supplied with Purina rodent chow ad libitum. The rats were acclimatised for 1 week prior to the study, and only healthy animals were used. They were housed in plastic cages with hardwood bedding. Rats weighing 175-250 g were used.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- peanut oil
- Details on exposure:
- Each rat was fasted overnight before being given a single oral dose of 32P-labeled white phosphorus in peanut oil. The dose was approximately 10% of the LD50, spiked with 10 µi of radiolabel. A volume of 1 ml/100 g bw was administered. An additional group of rats were given 5 consecutive daily doses.
- Duration and frequency of treatment / exposure:
- Single oral dose or 5 days of dosing.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
The dose was approximately 10% of the LD50, spiked with 10 µi of radiolabel.
- No. of animals per sex per dose / concentration:
- No information available.
- Control animals:
- not specified
- Positive control reference chemical:
- Not examined.
- Details on study design:
- A single oral dose of radiolabelled material was adminsitered to female rats then tissues and excreta were assayed for radioactivity.
- Details on dosing and sampling:
- After dosing each rat was placed immediately in a metabolism cage with food and water available ad libitum. Expired CO2 and urine and faeces were collected. At the end of each experiment, the rat was anaesthetised and aoritc blood collected in a heparinised syringe. Liver, kidneys, brain, lungs, and thigh muscle were removed, weighed and representative samples taken for analysis of radioactivity. The gastrointestinal tract (GI) plus contents were removed and weighed and assayed for radioactivity.
- Statistics:
- None reported.
Results and discussion
- Preliminary studies:
- Not performed.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Total 32P absorbed reached a maximum of 60-65% of the administered radioactivity at 24 hours post-dosing. The amount of radioactivity remaining in the GI tract was 57%, 15.3% and 1.7% of the administered dose at the end of 4 hours, 1 day and 5 days, respectively. All the tissues from the rats receiving 5 daily doses contained 4.1 to 10.5 times as much radioactivity as those receiving a single dose.
- Details on distribution in tissues:
- The liver contained the highest amount of radioactivity, representing 16.1% of the dose at 4 hours, 16.9% at 1 day, and 6.3% at 5 days. Significant amounts of radioactivity was also found in the blood and skeletal muscle. The radioactivity in the blood represented 6.1%, 4.1% and 1.7% of the administered dose at the end of 4 hours, 1 day and 5 days, respectively. The amount in muscle averaged 4%, 5.5%, and 6% at 4 hours, 1 day and 5 days.
- Details on excretion:
- Most of the absorbed radioactivity was excreted in the urine, averaging 17.1% of the administered dose at 4 hours, 34.5% at 1 day, and 46.7% at 5 days. 2%, 16.6% and 33% of the radioactivity was recovered in the faeces at the end of 4 hours, 1 day and 5 days, respectively.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Thin layer chromatography of urine samples indicated the metabolites consisted of two classes of compounds, one of which corresponded to inorganic phosphate. TLC analysis of liver extracts also demonstrated two classes of metabolites with similar properties to those in urine.
Any other information on results incl. tables
At 4 hours the radioactivity levels were in the order of liver > kidneys > lungs > spleen > bone > muscle > brain.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: the results of the study indicate that the substance is incorporated into the phosphate pool
White phosphorus was moderately absorbed after oral administration in the rat and was rapidly distributed and excreted. The results of the study indicate that a proportion of the administered substance is incorporated into the phosphate pool - Executive summary:
The toxicokinetics of radiolabelled white phosphorus were investigated in the rat using gavage administration. Radioactivity was well absorbed, with absorption essentially complete in 24 hours with 60 -65% of the administered dose. Most of the absorbed radioactivity was excreted in the urine, suggesting that the substance was metabolised since white phosphorous has limited solubility in water. Chromatography of urine samples indicated the metabolites consisted of two classes of compounds, one of which corresponded to inorganic phosphate. The liver contained high amounts of radioactivity. Skeletal muscle also contained a large percentage of the dose but this was thought to be due to the high muscle mass of the body. Only small amounts of radioactivity were found in other tissues. An additional repeat dose group indicated an accumulation of radioactivity in all tissues examined. The results of the study indicate that a proportion of the administered substance is incorporated into the phosphate pool
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