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EC number: 209-136-7 | CAS number: 556-67-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
93 d NOEC ≥4.4 µg/l based on embryo viability, hatching success, larval survival and growth, Oncorhynchus mykiss, measured, Springborn Laboratories, 1991b.
Key value for chemical safety assessment
Additional information
A 93-day chronic NOEC of ≥4.4 µg/l has been determined for the effects of the test substance on embryo viability, hatching success, larval survival and growth of early life stages of Oncorhynchus mykiss (Springborn Laboratories 1991b). No effects were seen at the highest concentration tested. Therefore, the overall long-term NOEC for fish is considered to be ≥4.4 µg/l.
However, to better define the potential NOEC, modelling (Mackay et al., 2015) to estimate fish critical body burden (CBB) levels and compare those CBB levels to those associated with a narcotic mode of action (MOA), under which the D4 and other volatile methyl siloxanes materials are proposed to operate (Redman et al., 2012, Mackay et al., 2015) was conducted. These results indicate that D4 dose levels up to 12 µg/l could have been successfully used in the D4 93-day trout ELS study without adverse effect.
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