Registration Dossier
Registration Dossier
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EC number: 221-221-0 | CAS number: 3033-77-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference not yet available. The validity of this study is limited due to scarce reporting.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Shell 1984 b
- Bibliographic source:
- In: USEPA, Chemical Hazard Information Profile, Draft Report, Epoxy/Chlorohydroxy propyltrimethylammonium chloride, 1984.
- Reference Type:
- secondary source
- Title:
- personal communication to Shell Company; Stanford Research Institute, Menlo Park, CA, USA, March 27, 1962
- Author:
- Shellenberger T E
- Year:
- 1 962
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,3-epoxypropyltrimethylammonium chloride
- EC Number:
- 221-221-0
- EC Name:
- 2,3-epoxypropyltrimethylammonium chloride
- Cas Number:
- 3033-77-0
- Molecular formula:
- C6H14NO.Cl
- IUPAC Name:
- N,N,N-trimethyl(oxiran-2-yl)methanaminium chloride
- Details on test material:
- IUCLID4 Test substance: no data
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Doses:
- 1500 and 3000 mg/kg bw
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 1 500 - 3 000 mg/kg bw
- Remarks on result:
- other: as stated in IUCLID 2000
Any other information on results incl. tables
In the lower dose group one rabbit died after 7 days of
administration. In the higher dose group, two rabbits died
in 5 h - 2 days. LD50 was estimated to be between 1500 -
3000 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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