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Diss Factsheets
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EC number: 211-074-0 | CAS number: 629-11-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Genetic toxicity in vitro was analyzed in a study which was performed according to OECD guideline 471 (BASF, 1988). Bacteria S. typhimurium TA 1535, TA 1537, TA 98 and TA 100 were treated with 20, 100, 500, 2500 and 5000 µg/plate 1,6-hexandediol with and without metabolic activation by a Aroclor 1254 pretreated rat liver S9 mix. As result, 1,6-hexandediol did not show mutagenic toxicity in this study using the two methods, preincubation and plate incorporation.
In another study, a mammalian cell gene mutation assay with Chinese hamster V79 cells was conducted under GLP in compliance
with OECD guideline 476 and EPA OPPTS 870.5300 (BASF, 1993). The cells were treated with 0.5, 1, 2.5 and 5 mg/ml
1,6-hexanediol for 4 and 24 hours in two trials with and without metabolic activation by Aroclor 1254 induced rat liver S9 mix.
After six to seven days in a selection culture containing thioguanine, cells were prepared and more than 50 cells were used for
evaluation of mutations in the HGPRT (hypoxanthine-guanine phosphoribosyl transferase) gene. As result, no gene mutations at the
HGPRT locus in V79 cells were reported in this mutagenicity assay and under the experimental conditions.
In addition, an in vitro mammalian chromosome aberration test could be taken into account for assessment since it was conducted
under GLP according to OECD guideline 473 and EU method B.10 (BASF, 1993). Chinese hamster V79 cells were treated with
doses of 0.3, 0.6 and 1.2 µg/ml 1,6-hexanediol with and without metabolic activation for four hours. After an expression time of 18 or 28 hours, the cells were fixed and a minimum of 100 cells were analyzed for chromosomal aberrations. As result, 1,6-Hexandiol
was found neither to be a chromosome-damaging (clastogenic) agent nor to have any aneugenic activity under in vitro conditions using V79 cells.
Short description of key information:
1,6-Hexanediol is non mutagenic in all in vitro mutagenicity tests conducted so far (OECD 471, 473, 476).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Due to the negative results in different in vitro guideline studies, no classification as mutagenic is necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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