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EC number: 201-800-4 | CAS number: 88-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin: Not irritating
Eyes: May cause irreversible effects.
Respiratory: Irritating to respiratory system
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin Irritation / Corrosion
Skin irritation/corrosion of N-Vinyl-2-pyrrolidone (nVP) has been examined in 2 well documented and reliable non-GLP non-guideline studies. In a test conducted using Draize methodology, only slight erythema (individual scores of 1 out of a possible 4) was observed in each animal 24 and 72 hours after exposure of intact skin of six New Zealand White rabbits to 0.5 ml of undiluted test substance for 24-hours under occlusive dressing and there was no evidence of edema (BASF AG, 1978). These data are supported by an earlier study which showed only slight erythema (highest score of 1.67 out of possible 4 observed in 1 animal) after exposure to intact skin of eight Vienna White rabbits to 2.5 ml of undiluted test substance under occlusive wrap for 20 hours followed by an 8-day observation period (BASF AG, 1963). Edema was evident in only one animal, resulting in a score of 1.67 out of a possible 4. In addition, several animals died during the test and is presumed to be the result of treatment-related toxicity.
Eye Irritation / Corrosion
Eye irritation/corrosion of N-Vinyl-2-pyrrolidone (nVP) has been examined in 2 well documented and reliable non-GLP non-guideline studies. In a test conducted using Draize methodology, one eye of each of 6 New Zealand White rabbits was exposed to 0.1 ml of undiluted test substance and effects were scored at 1, 24, 48, and 72 hours (BASF AG, 1978). Mean scores for individual animals during the 24-72 hour time period were as follows: corneal opacity (2.0 out of a possible 4.0 for 3 of the 6 animals and 1.7 or less for the remaining 3 animals), iritis (1.0 out of a possible 2.0 for each of the 6 animals), conjunctivae redness (2.0 out of a possible 3.0 in 5 of the 6 animals and 1.7 in the remaining animal), conjunctivae chemosis (2.0 or greater out of a possible 4.0 in all 6 animals). There were no signs of reversibility during the 7 days following exposure. These data are supported by an earlier study where 0.05 ml of undiluted test substance was applied to one eye of each of 2 Vienna White Rabbits and effects scored at 1, 3, 24, 48 and 72 hours and 4, 7 and 9 days following treatment (BASF AG, 1963). Mean scores for individual animals during the 24-72 hour time period were as follows: corneal opacity (2.0 and 2.33 out of a possible 4.0), iritis (1.0 in both animals out of a possible 2.0), conjunctivae redness (1.0 in both animals out of a possible 3.0), and conjunctivae chemosis (0.00 and 0.33 out of a possible 4.0). Effects on the cornea and iris were not reversible.
Conclusion
Based on these results, nVP should be regarded as capable of causing serious irreversible damage to the eye but should not be regarded as a skin irritant.
Effects on eye irritation: irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Skin irritation
Based on the finding of no significant irritation in the key study (BASF AG, 1978), N-vinyl-2-pyrrolidone (NVP) should not be classified under the EU DSD criteria (EU Directive 67/548/EEC) nor under the EU CLP criteria (Regulation (EC) 1272/2008).
Eye irritation
Based on evidence of serious and irreversible eye damage in the key study (BASF AG, 1978), N-vinyl-2-pyrrolidone (NVP) should be classified as R41 (Risk of serious damage to eyes) under the EU DSD criteria (EU Directive 67/548/EEC) and assigned to Category 1 (Irreversible effects on the eye) under the EU CLP criteria (Regulation (EC) 1272/2008).
Respiratory irritation
Based on pathological observations of respiratory effects in the key study (lung with acute congestion hyperemia, partially edematic) in rats exposed to NVP (nose only, aerosol) at a concentrations up tp of 5.63 mg/L for 4-hours (BASF, 1979), NVP is classified as R37 (Irritating to respiratory system under the EU DSD criteria (EU Directive 67/548/EEC) and Specific Target Organ Toxicity - Single Exposure (STOT-SE), Category 3 (Transient target organ effects) under the EU CLP criteria (Regulation (EC) 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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