Refractories, fibers, aluminosilicate

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

Januarty 2002 to Febbruary 2002

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: A small study carried out using the exposed population, a deficiency was that the study only considered workers in the UK factories of the study sponsors

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Study type:

medical screening

Endpoint addressed:

skin sensitisation

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Clinical examination of workforce by expert dermatologist

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

oxo[(oxoalumanyl)oxy]alumane; silanedione

EC Number:

604-314-4

Cas Number:

142844-00-6

Molecular formula:

amorphous glass Si(n)O(3n+1) polymeric anions bonded to Zr and Al(3+)

IUPAC Name:

oxo[(oxoalumanyl)oxy]alumane; silanedione

Details on test material:

- Name of test material (as cited in study report): Ceramic fibre, Zircon

Method

Type of population:

occupational

Ethical approval:

confirmed, but no further information available

Details on study design:

Questionnaire and full clinical examination

Results and discussion

Results:

The results of this study performed in 2 RCF manufacturing facilities in UK found no evidence of skin disease leading to chronic change or any skin problem requiring any long term treatment, causing long term changes to the skin, causing time off work or fundamentally altering an employees' life style. The spectrum of skin disease found in these populations followed a normal distribution and had no association to exposure to RCF.

Any other information on results incl. tables

Table 1 Profile of employees with and without skin disease

	WITH Complaint of skin Disease	WITHOUT Complaint of skin Disease
Average age	45.75	42.73
Duration of Employment	13.2 years	11.4 years

Table 2 –Profile of itch when first started

SITE	Duration	Findings on examination
Arms/Face	Few days	Nil
Arms	Few days	Nil
Neck/Arms/Face	2-3 weeks	Nil
Face/Arms	2-3 Weeks	Nil
Forearms	2 months	Psoriasis
Neck/Arms/Legs	2 weeks	Acne

Applicant's summary and conclusion

Executive summary:

This study was undertaken following a publication of positve results on skin effects from Poland the Polish dermatologist involved in the earlier study also took part in this study and confirmed the absence of any effects on these workers. The origin of the skin lessions seen in Poland remains unknown.