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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 206-058-5 | CAS number: 298-12-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
- In a dermal sensitisation study with Glyoxylic Acid 50% in acetone, 8 - 12
weeks old female Balb/c mice were tested using a combined Local Lymph Node
Assay. The test concentrations were 1.25 , 2.5, 5.0, 10 , 20 or 40 %.
Signs of skin irritation were seen at 40%. Glyoxylic Acid 50% tested
positive in the LLNA with an EC3 value of 5.05% and a maximal stimulation
index of 23.9 achieved at the 40% test concentration. Significant
increases were observed in the B220+ cell population in the draining lymph
nodes. No changes were identified in the IgE+B220+ cell population in the
draining lymph nodes or total serum IgE levels; this suggests that
Glyoxylic Acid 50% functions as a T-cell-mediated contact sensitizer
(Anderson SE, 2008). In a dermal sensitisation study with Glyoxylic Acid
in water young Pirbright white Guinea pigs (15 males) were tested using a
method similar to Freund's complete adjuvant test (Induction: 10
injections intracutaneous, Challenge 80 % epicutaneous, open). In this
study 100 % (15/15) of the animals treated with Glyoxylic acid showed a
skin sensitization response. In this study, Glyoxylic acid is a potent
dermal sensitiser (Hoechst, 1975).
Migrated from Short description of key information:
Glyoxylic acid was sensitising in the LLNA test and a guinea pig sensitisation test similar to Freund's complete adjuvant test.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- There are no human data available
indicative of a respiratory sensitisation. Lymph node phenotyping
performed in the LLNA published by Anderson (2008) suggested that the
Glyoxylic acid response is a TH1 rather than a TH2 response, indicating no
respiratory sensitising potential.
Migrated from Short description of key information:
There is no data available indicating a respiratory sensitising potential.
Justification for classification or non-classification
Based on the results of the sensitisation studies, Glyoxylic Acid 50% is subject to classification and labelling as follows:
R43 (may cause sensitisation by skin contact) according to Directive 67/548/EEC
Cat 1 / H317 ( may cause an allergic skin reaction) according to Regulation 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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