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Diss Factsheets
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EC number: 202-496-6 | CAS number: 96-29-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The test parameters evaluated in this study comply with an in-house protocol that is expected to be robust, well documented and scientifically acceptable.
- Qualifier:
- according to guideline
- Guideline:
- other: BASF in-house protocol
- Principles of method if other than guideline:
- Growth inhibition was evalated for 17 hours in the bacteria Pseudomonas putida.
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Test organisms (species):
- Pseudomonas putida
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 17 h
- Hardness:
- Not reported
- Test temperature:
- 20
- pH:
- Not reported
- Dissolved oxygen:
- Not reported
- Salinity:
- Not reported
- Nominal and measured concentrations:
- Not reported
- Duration:
- 17 h
- Dose descriptor:
- EC10
- Effect conc.:
- ca. 177 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Duration:
- 17 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 281 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Duration:
- 17 h
- Dose descriptor:
- other: EC90
- Effect conc.:
- ca. 544 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Conclusions:
- For the bacteria Pseudomonas putida, the 17-hour EC10, EC50 and EC90 for growth inhibition are 177, 281 and 544 mg MEKO/L, respectively.
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: This study does not provide sufficient experimental details and was not conducted according to GLPs
- Qualifier:
- no guideline available
- Guideline:
- other:
- GLP compliance:
- no
- Details on test solutions:
- The concentration at which effects still occured was estimated by a dilution series.
- Test organisms (species):
- Pseudomonas sp.
- Test type:
- not specified
- Water media type:
- freshwater
- Dose descriptor:
- LOEC
- Effect conc.:
- >= 630 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Conclusions:
- For a Pseudomonas sp., the LOEC for an effect is estimated to be >630 mg MEKO/L. The basis for effect, duration of exposure, and the other MEKO concentrations tested are not known.
Referenceopen allclose all
Description of key information
The 17-h EC10 for Pseudomonas putida of 177 mg/L will be used in the assessment.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 177 mg/L
Additional information
In a static freshwater micro-organism toxicity study with Pseudomonas putida (BASF Ecotoxicology Laboratory, 1988), performed according to BASF protocols, the 17-h EC10 is 177 mg/L and the 17-h EC50 is 281 mg/L, based on growth inhibition. No data are available on the GLP status and analytical monitoring. In another freshwater study with Pseudomonas sp., for which only information from secondary sources is available (Meinck et al., 1968) a LOEC of = 630 mg/L is reported. The value from the study by BASF Ecotoxicology Laboratory (1988) will be used in the assessment as the results are more critical and results from secondary sources cannot be used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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