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EC number: 500-101-4 | CAS number: 38294-64-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This is a GLP Guideline study. All the validity criteria were met. Analytical test material characterization and quantification was included in the study report.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1010 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Because BADGE IPD (#33) is a multi-component substance of limited solubility, WAFs were created and analyzed via non-purgable organic carbon (NPOC) and all values reported are nominal. This method is outlined in the OECD guidance (No. 23) on Aquatic Testing of Difficult Substances and Mixtures. NPOC was measured in test solutions at test initiation and termination.
- Vehicle:
- no
- Details on test solutions:
- A preliminary non-GLP trial indicated that a dosing (loading rate) of 100 mg BADGE-IPD (#33)/L required 24 hours of stirring to reach an equilibrium in water-soluble components (i.e., a change of <20% measured dissolved organic carbon concentrations between two sampling points); therefore, the WAF preparations for all test solutions were stirred for approximately 24 hours prior to test initiation.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Neonates were only used from daphnids which have had at least 3 broods. The day before neonates were needed for testing (<24 hours prior to test initiation), neonates within the culture vessels were removed leaving only adult daphnids in the vessels; these neonates were not used in the study. On the following day, neonates produced overnight in these same culture vessels were again removed from the vessels and placed into a glass beaker containing laboratory dilution water. These neonates (<24 hours old) were held in an incubator until used for the study.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- None
- Hardness:
- 52 – 56 mg CaCO3/L
- Test temperature:
- 19 – 20 °C
- pH:
- 7.4 – 7.8
- Dissolved oxygen:
- 9.0 – 9.1 mg/L (101 - 102% saturation)
- Nominal and measured concentrations:
- Nominal concentrations: 0 (control), 4.3, 9.4, 21, 46, and 100 mg BADGE-IPD (#33)/L
- Details on test conditions:
- Dissolved oxygen levels ranged from 9.0 to 9.1 (i.e., 101 - 102% saturation), temperature ranged from 19 to 20°C, and pH ranged from 7.4 to 7.8. Light intensity ranged from 914 to 1156 lux. Water hardness was 52 mg CaCO3/L in the control and 56 mg CaCO3/L in the highest loading rate. Alkalinity was 30 CaCO3/L in the control water and 40 mg CaCO3/L in the highest loading rate. Conductivity was 179 and 221 µmhos/cm in the control and highest treatment level, respectively.
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- 11.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL = 9.41-13.0
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 4.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Following 24 hours of exposure, there was immobility observed in 20, 70, 100, and 100%, of the daphnids at the 9.4, 21, 46, and 100 mg BADGE-IPD (#33)/L loading rates, respectively. At test termination (48-hours of exposure), immobility was observed in 30, 100, 100, and 100% of the daphnids in the 9.4, 21, 46, and 100 mg BADGE-IPD (#33)/L loading rates, respectively. No immobility was observed at the 4.3 mg BADGE-IPD (#33)/L test level or the water control during the conduct of the study. No changes in daphnid behavior or appearance were observed at any test level.
- Reported statistics and error estimates:
- The acute toxicity values for Daphnia magna exposed to BADGE-IPD (#33) over a 48-hour static exposure period and based on nominal loading rates, were as follows: The 24-hour EL50 was 15.2 mg BADGE-IPD (#33)/L (95% confidence limits 12.2 – 18.9; slope 4.7); the 48-hour EL50 was 11.1 mg BADGE-IPD (#33)/L (95% confidence limits 9.41 – 13.0). The 48-hour NOELR was 4.3 mg BADGE-IPD (#33)/L.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The acute toxicity values for Daphnia magna exposed to BADGE-IPD (#33) over a 48-hour static exposure period and based on nominal loading rates, were as follows: 24-hour EL50 was 15.2 mg BADGE-IPD (#33)/L (95% confidence limits 12.2 – 18.9; slope 4.7); 48-hour EL50 was 11.1 mg BADGE-IPD (#33)/L (95% confidence limits 9.41 – 13.0). The 48-hour NOELR was 4.3 mg BADGE-IPD (#33)/L.
- Executive summary:
The purpose of this study was to evaluate the acute toxicity of BADGE-IPD (#33) to the daphnid, Daphnia magna. Based on the limited solubility of this multi-component test material, water accommodated fractions (WAFs) were prepared and used for exposures (OECD, 2000) at the following loading rates: 4.3, 9.4, 21, 46, and 100 mg BADGE-IPD (#33)/L. The data collected were used to calculate the 24- and 48-hour EL50 values (the loading rate estimated to immobilize 50% of the daphnids after 24 and 48 hours of exposure, respectively) and a 48-hour no-observed-effect-loading rate (NOELR). The acute toxicity values for Daphnia magna exposed to BADGE-IPD (#33) over a 48-hour static exposure period and based on nominal loading rates, were as follows: the 24-hour EL50 was 15.2 mg BADGE-IPD (#33)/L (95% confidence limits 12.2 – 18.9; slope 4.7); the 48-hour EL50 was 11.1 mg BADGE-IPD (#33)/L (95% confidence limits 9.41 – 13.0). The 48-hour NOELR was 4.3 mg BADGE-IPD (#33)/L
Reference
None
Description of key information
Single daphnia magna study
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 11.1 mg/L
Additional information
The purpose of this study was to evaluate the acute toxicity of BADGE-IPD (#33) to the daphnid, Daphnia magna. Based on the limited solubility of this multi-component test material, water accommodated fractions (WAFs) were prepared and used for exposures (OECD, 2000) at the following loading rates: 4.3, 9.4, 21, 46, and 100 mg BADGE-IPD (#33)/L. The data collected were used to calculate the 24- and 48-hour EL50 values (the loading rate estimated to immobilize 50% of the daphnids after 24 and 48 hours of exposure, respectively) and a 48-hour no-observed-effect-loading rate (NOELR). The acute toxicity values for Daphnia magna exposed to BADGE-IPD (#33) over a 48-hour static exposure period and based on nominal loading rates, were as follows: the 24-hour EL50 was 15.2 mg BADGE-IPD (#33)/L (95% confidence limits 12.2 – 18.9; slope 4.7); the 48-hour EL50 was 11.1 mg BADGE-IPD (#33)/L (95% confidence limits 9.41 – 13.0). The 48-hour NOELR was 4.3 mg BADGE-IPD (#33)/L
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