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Diss Factsheets
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EC number: 202-951-9 | CAS number: 101-54-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The chronic toxicity of 4-ADPA to aquatic invertebrates (Dapnia magna) was conducted in a semistatic reproduction test according OECD Guideline for Testing of Chemicals 202, part II, 04. April 1984. After 21 days of exposure a NOEC-reporduction of 0.04 mg/l (nominal), LOEC-reproduction of 0.13 mg/l (nominal), EC50-reproduction of 0.1 mg/l (nominal) and EC50-imboilisation of 0.52 mg/l (nominal) were determined (Bayer, 1992).
Key value for chemical safety assessment
Additional information
The analytical monitoring showed that at the nominal NOEC (reproduction) of 0.04 mg/l, 4-ADPA decreased significantly during 3 h of stirring in an open beaker to 38 % (0.015 mg/l) before the start of the experiment and subsequently during the incubation period to less than the determination limit of 0.01 mg/l. According to the stability in water study from BIS 2004, the fast lost of 4-ADPA during the preparation period of only 3 hours cannot be only up to abiotic degradation alone. The adsorption of 4 -ADPA at low concentrations to glass wall can be also a reason.The similar effect has been observed before in inherent biodegradability test from Bayer 1989 (Currenta,2009). Unfortunately, not all of the nominal concentrations were confirmed analytically at the starting point of the experiments, and hence statistical analyses based on measured results were not posssible. Consequently, nominal concentrations were used to calculate EC50, NOEC and LOEC.
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