Registration Dossier
Registration Dossier
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EC number: 231-177-4 | CAS number: 7440-69-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- EC50 for microorganisms:
- 175.4 mg/L
Additional information
The key study is a GLP-conform study according to OECD 209 guideline on the effect of bismuth subnitrate (Bi5O(OH)9(NO3)4) on the activated sludge respiration inhibition after seven days equilibration of the test substance in deionised water (Egeler et al., 2010; Klimisch 1). A concentration-related effect was observed only in the highest concentration level (300 mg Bi/L), where respiration compared to the controls was inhibited by approximately 17%. Since this inhibition was not statistically significant at p ≤ 0.05, the NOEC is ≥ 300 mg Bi/L. An EC10 of 175.4 mg Bi/L was calculated based on nominal concentrations.
The measured dissolved Bi concentrations were <0.3 mg Bi/L, except for highest dose, where an average concentration of 14.1 mg Bi/L was measured (corresponding to 4.7% of the total nominal concentration). The NOEC and EC10 expressed as dissolved Bi concentration (based on recovery of 4.7%) are ≥14.1 and 8.2 mg Bi/L.
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