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EC number: 700-371-5 | CAS number: 178535-25-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- IN-LIFE DATES: From: 1 July 2002 To: 18 July 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was carried out according to OECD guideline 423 and EU Method B1 and follows GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- ethylbenzene
- EC Number:
- 700-371-5
- Cas Number:
- 178535-25-6
- IUPAC Name:
- ethylbenzene
- Details on test material:
- - Name of test material (as cited in study report): Ethylbenzene, manuf. of, distn. residues, distn. lights.
- Substance type: Solvent for petroleum additives
- Physical state: Clear light yellow liquid
- Purity test date: 100%
- Lot/batch No.: P0204-1936
- Stability under test conditions: Stable for the duration of the study (single dose only prepared on the day of dosing)
- Storage condition of test material: Room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan U.K. Ltd, Bicester, Oxon, UK
- Age at study initiation: 5-7 weeks of age
- Weight at study initiation: 87 - 117 g
- Fasting period before study: overnight prior to dosing and 4 hours after dosing
- Housing: Housed in groups of 3 in metal cages with wire mesh floors
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: 5 days prior to the start of treatment
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3C
- Humidity (%): 40 - 70%
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12 hours light/ 12 hours dark
IN-LIFE DATES: From: 1 July 2002 To: 18 July 2002
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 mg/mL
- Amount of vehicle (if gavage): 15 g using a glass syringe and metal cannula
MAXIMUM DOSE VOLUME APPLIED: Appropriate dose volume of the test substance was administered
DOSAGE PREPARATION (if unusual):
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: The starting dose was 2000 mg/kg bw as per the guideline. - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 animals/sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed at frequent intervals in the day of dosing and twice day thereafter until Day 15. Mortality/viability were checked ar least twice daily for any mortalities. Bodyweight was recorded on prior to dosing and once a week thereafter.
- Necropsy of survivors performed: yes
- Other examinations performed: All animals were subjected to a macrospcopic examination at study termination on day 15. - Statistics:
- No statistical method was used since it is a limit test.
Results and discussion
- Preliminary study:
- The study is a limit test.
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the course of the study.
- Clinical signs:
- other: Clinical signs such as confined to light purple coloured urine was reported in all animals and persisted until day 4. Salivation and brown staining to the muzzle of two males and piloerection and hunched posture observed in one male. All animals had recov
- Gross pathology:
- No abnormalities were reported during macroscopic examination
- Other findings:
- All other findings were reported.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute lethal oral dose (LD50) to rats of Ethylbenzene, manuf. of, distn. residues, distn. lights. was demonstrated to be greater than 2000 mg/kg bw. On this basis, Ethylbenzene, manuf. of, distn. residues, distn. lights. does not warrant any classification according to Directive 67/548/EEC and Regulation (EC) No 1272/2008
- Executive summary:
A group of three fasteed female rats were administered a single oral gavage dose of Ethylbenzene, manuf. of, distn. residues, distn. lights. at 2000 mg/kg bw. Animals were monitored for mortality and clinical signs at frequent intervals on the day of dosing and twice a day thereafter until Day 15. Bodyweights were recorded prior to dosing and on days 8 and 15. Gross necropsy was carried out on day 15. Clinical signs were confined to confined to light purple coloured urine was reported in all animals and persisted until day 4. Salivation and brown staining to the muzzle of two males and piloerection and hunched posture observed in one male. All animals had recoved by day 4 and gained weights throughout the course of the study. No abnormalities were recorded at macroscopic examination. The acute lethal oral dose (LD50) to rats of Ethylbenzene, manuf. of, distn. residues, distn. lights. was demonstrated to be greater than 2000 mg/kg bw. On this basis, Ethylbenzene, manuf. of, distn. residues, distn. lights. does not warrant any classification according to Directive 67/548/EEC and Regulation (EC) No 1272/2008
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