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Diss Factsheets
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EC number: 232-142-6 | CAS number: 7789-06-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report. Results presented in sufficient detail, but methods were only briefly described.
Data source
Reference
- Reference Type:
- publication
- Title:
- Accumulation of toxic metals in male reproductive organs.
- Author:
- Danielsson, B. R. G., L. Dencker, et al.
- Year:
- 1 984
- Bibliographic source:
- Arch Toxicol.Suppl. 7: 177-180.
Materials and methods
- Objective of study:
- distribution
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The accumulation of chromium(VI) in male reproductive organs of mice was presented.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium dichromate
- EC Number:
- 234-190-3
- EC Name:
- Sodium dichromate
- Cas Number:
- 10588-01-9
- Details on test material:
- Sodium dichromate Na2[51]Cr2O7 obtained from the Radiochemical Centre, Amersham, England.
No details presented.
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No details presented.
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- Single injection.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
No data
- No. of animals per sex per dose / concentration:
- No data
- Control animals:
- no
- Details on study design:
- - Dose selection rationale: no data
- Rationale for animal assignment (if not random): no data - Details on dosing and sampling:
- 72 h afters i.v. injection the animals were killed ad tissues fixed. Cr(VI) in formalin-fixed testicular tissue was studied by microautoradiography
- Statistics:
- No data
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on distribution in tissues:
- Microautoradiographic studies showed a relatively large uptake of Cr in the intestinal tissues. The uptake was probably concentrated to Leydig cells. No radioactivity was detected in blood vessels or in the spermatogenetic epithelium.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no data
After an intravenous injection of radiolabelled sodium dichromate the label was taken up in the interstitial tissues. No radioactivity could be detected in blood vessels or the spermatogenic epithelium. The authors speculated that the Leydig cells could be the primary target of chromium in the testis. - Executive summary:
A microautoradiographic study of the testis (no methodological details were provided) showed that after an intravenous injection of radiolabelled sodium dichromate the label was taken up in the interstitial tissues (Danielsson, Dencker et al. 1984). No radioactivity could be detected in blood vessels or the spermatogenic epithelium. The authors speculated that the Leydig cells could be the primary target of chromium in the testis.
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