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Diss Factsheets
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EC number: 202-131-0 | CAS number: 92-15-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed OECD and GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2'-methoxyacetoacetanilide
- EC Number:
- 202-131-0
- EC Name:
- 2'-methoxyacetoacetanilide
- Cas Number:
- 92-15-9
- Molecular formula:
- C11H13NO3
- IUPAC Name:
- N-(2-methoxyphenyl)-3-oxobutanamide
- Details on test material:
- - Name of test material (as cited in study report): Acetessig-o-anisidid TTR
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- physiological saline
- Controls:
- no
- Amount / concentration applied:
- 500 mg mixed with 0.35 ml physiol. saline
- Duration of treatment / exposure:
- Exposure period: 4 hrs. After the exposure period all remnants of the test substance were carefully removed from the skin with warm tap water.
- Observation period:
- 72 hrs
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: mean of animal # 1, 2 each
- Time point:
- other: Mean of 24, 48, 72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: no effects at any time
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 0.3
- Reversibility:
- fully reversible within: 48h
- Irritation parameter:
- edema score
- Basis:
- other: mean of animal # 1, 2, 3 each
- Time point:
- other: mean of 24, 48, 72h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: no effects at any time
- Irritant / corrosive response data:
- No signs of irritation/corrosion except very slight erythema in a single animal (at 24h) have been observed during the entire study period.
- Other effects:
- no other effects, during entire study period
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Acetoacet-o-anisidide was neither skin irritating nor skin corrosing in this test.
- Executive summary:
Acetessig-o-anisidid TTR was tested for its skin irritating or skin corrosive properties according to OECD 404.
Following this protocol 500 mg Acetessig-o-anisidid mixed with 0.35 ml of physiol. saline was applied to the shaved skin of New Zealand albino rabbits. After four hours exposure time the semiocclusive covering was removed and the application site carefully rinsed to remove adhesive substance. In the following 72 hours the animals were periodically examined for signs of skin irritation and or corrosion. Mean scores (mean of 24, 48, 72 h) were calculated for oedema and erythema for each rabbit.
All calculated mean scores were 0 except for one rabbit whose mean score for erythema amounts to 0.3 but was fully reversible within 48h. Based on these findings the test substance is neither skin irritating nor skin corrosive in this test.
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