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EC number: 206-696-4 | CAS number: 367-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
NaTG is toxic by ingestion and harmful in contact with skin.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 31 August to 01 December 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- ANIMALS
- Source: RCC, Ltd, Biotechnology & Animal breeding division, Wölferstrasse, 4 CH-4414 Füllinsdorf , Switzerland.
- Age: 8-10 weeks
- Weight: 217.1-234.7 g (M), 158.9-181.9 g (F)
- Acclimatization: 1 week
- Housing: 3 per sex
- Diet: ad libitum Pelleted standard Kliba 3433, batch n° 03/00 and 04/00, rat maintenance diet (Provimi Kliba AG, CH-4303 Kaiseraugst)
- Water: ad libitum tap water
CONDITIONS:
- Air changes: 10-15/hour
- Temperature: 21-23.5 °C
- Relative Humidity: 36-57%
- Light-Dark cycle: 12/12 - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The animals received a single dose of the test item on a 200, 50 or 25 mg/kg bw by oral gavage following fasting for approx. 17 hours, but with free access to water. Food was provided again 3 hours after dosing.
- Doses:
- 25, 50 and 200 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Animals were observed once daily during the acclimatization phase and then 1, 2, 3 and 5 hours after administration on day 1 and twice daily for surviving animals during days 2-15. Surviving animals were weighted on day 1, 8 and 15. All abnormalities and clinical signs were recorded. All animals were necropsied and examined macroscopically.
- Statistics:
- None
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 50 - <= 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All males and females treated at 25 and 50 mg/kg survived until scheduled necropsy. Two out of 3 females treated at 200 mg/kg died on day 1. The following animals were treated and percentage mortality was observed:
Males Females
Group 1 (200 mg/kg) 66%
Group 2 (50 mg/kg) 0%
Group 3 (50 mg/kg) 0%
Group 4 (25 mg/kg) 0%
Group 5 (25 mg/kg) 0% - Clinical signs:
- other: No clinical signs were observed during the observation period in all 50 mg/kg treated males and females and all 25 mg/kg treated females. Slightly ruffed fur was observed in all 200 mg/kg treated females from 1 to 3 hours (2 females) or from 1 or 5 ho
- Gross pathology:
- A distended stomach with gas was observed at the unscheduled necropsy in two females treated at 200 mg/kg. No macroscopic findings were observed at the other scheduled necropsy.
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The median lethal dose is between 50 and 200 mg/kg in rat after a single oral administration in both sexes.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 50 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7-Mar-2003 - 19-Sep-2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- French Republic, Prime Minister, Interministerial Group on Chemicals (GIPC)
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Breeder: Janvier, Le Genest-Saint-Isle, France
- Age at study initiation: approximately 9 weeks
- Weight at study initiation: 290 ± 7 g for the males and 228 ± 6 g for the females
- Water and food: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 30 to 70
- Ventilation: approximately 12 cycles/hour of filtered, non-recycled air. - Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- - Area of exposure: a dorsal area of the skin (approximately 5 cm x 6 cm for the females and 5 cm x 7 cm for the males)
- % coverage: approximately 10%
- Type of wrap if used: hydrophilic gauze pad held in contact with the skin by means of an adhesive hypoallergenic aerated semi-occlusive dressing and a restraining bandage. - Duration of exposure:
- 24 h
- Doses:
- A single dose of 2000 mg/kg of the test item in its original form was placed on a hydrophilic gauze pad (pre-moistened with 2 mL of PEG 400) and then applied to the clipped area of the skin.
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent no treatment
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - <= 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 798 - <= 1 596 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- At the 2000 mg/kg dose-level, all females were found dead or died on day 2. No clinical signs were observed prior to death in four of them and the last one was in coma prior to death.
- Clinical signs:
- other: At the 2000 mg/kg dose-level, in males, no clinical signs were noted. Dryness of the skin was recorded in 3/5 animals on day 3; it persisted, together with crusts, in one of them until day 7. At 1000 mg/kg, no clinical signs were recorded. A very slight o
- Gross pathology:
- Macroscopic examination of the main organs of the animals revealed no apparent abnormalities.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the experimental conditions, the dermal LD50 of NaTG is higher than 2000 mg/kg in male rats and is between 1000 and 2000 mg/kg in female rats.
- Executive summary:
The test item was applied to the skin of one group of ten Sprague-Dawley rats (five males and five females).
The application was performed with the test item in its original form at the dose-level of 2000 mg/kg. Water was used to moisten the gauze pad and ensure a good contact with the skin. The test site was then covered by a semi-occlusive dressing for 24 hours.
Clinical signs, mortality and body weight gain were checked for a period of 14 days following the single application of the test item.
At the 2000 mg/kg dose-level, all females were found dead or died on day 2. No clinical signs were observed prior to death in four of them and the last one was in coma prior to death.
In males, no clinical signs and no mortality occurred. Dryness of the skin was recorded in 3/5 animals on day 3; it persisted, together with crusts, in one of them until day 7.
At 1000 mg/kg, no clinical signs and no mortality occurred. A very slight or well-defined erythema, together with dryness of the skin in 3/5 animals, was observed in all females from day 4 up to day 8; some of these reactions persisted in 3/5 animals until day 10, 11 or 13.
A reduced body weight gain was seen in 4/5 females receiving the test item at the dose-level of 1000 mg/kg between day 1 and day 8. The body weight gain of the other animals was similar to that of CIT historical control animals.
All animals were subjected to necropsy, but no apparent abnormalities were observed in any animal.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 000 mg/kg bw
- Quality of whole database:
- LD50 determined with NaTG (LD50 is >1000 mg/kg bw for female rats.
Additional information
Thioglycolic acid and its salts are toxic by oral administration. When expressed as thioglycolate anion, the LD50values of thioglycolic acid and its salts are quite accurately in the same dose range.
Justification for selection of
acute toxicity – oral endpoint
LD50 determined via ATC method with NaTG
Justification for classification or non-classification
Based on acute oral and dermal toxicity data in rats.
Classification:
DSD: T, R25. Toxic if swallowed. Xn, R21. Harmful in contact with skin.
EU-GHS: Acute tox cat. 3. H301. Toxic if swallowed. Acute tox cat. 4. H312: Harmful in contact with skin.
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