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EC number: 211-670-0 | CAS number: 683-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific standards, is sufficiently documented, and acceptable for assessment. Source and purity of test material not reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- nda
- GLP compliance:
- no
- Remarks:
- Pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dibutyltin dichloride
- EC Number:
- 211-670-0
- EC Name:
- Dibutyltin dichloride
- Cas Number:
- 683-18-1
- Molecular formula:
- C8H18Cl2Sn
- IUPAC Name:
- dibutyltin dichloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: nda
- Age at study initiation: nda
- Weight at study initiation: 75-117 g
- Fasting period before study: 18-20 hours
- Housing: Type II macrolide cage, grated bottom (1 animal per cage)
- Diet (e.g. ad libitum): Altromin, ad libitum
- Water (e.g. ad libitum): Tap water, ad libitum
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-23°C
- Humidity (%): 55-65%
- Air changes (per hr): nda
- Photoperiod (hrs dark / hrs light): nda
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration: Concentrations used for the test are: 100, 200, 300, 400 and 500 mg/kg
- Amount of vehicle: 0.5g carboxymethyl cellulose in 100 mL distilled water
- Justification for choice of vehicle: nda - Doses:
- Concentrations used for the test are: 100, 200, 300, 400 and 500 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females (10 in total per dose)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 21 days
- Frequency of observations and weighing: Rats were observed daily to determine mortality
- Necropsy of survivors performed: Yes - Statistics:
- nda
Results and discussion
- Preliminary study:
- n/a
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 219 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 157 - 277
- Remarks on result:
- other: LD50 value calculated using probit analysis
- Mortality:
- In the 100 mg/kg dose 1 female died on day 4.
In the 200 mg/kg dose 3 rats died on day 4 (1M, 2F), 1 female died on day 5 and 1 female died on day 6.
In the 300 mg/kg dose 4 rats died on day 4 (2M, 2F), 1 female died on day 8.
In the 400 mg/kg dose 1 male died on day 2, 3 rats died on day 3 (2M, 1F), 4 rats died on day 4 (2M, 2F) and 1 female died on day 13.
In the 500 mg/k dose all rats had died by day 5. - Clinical signs:
- other: From doses of 200 mg/kg up, apathy, dyspnoea and diarrhea was observed.
- Gross pathology:
- Observations include:
Hydrops ascites; focal fibrocaseous peritonitis with deformation of the abdominal organs; thickening of the cutaneous gastric mucosa; hyperemia and hemorrhagic erosion of the glands in the gastric mucosa; catarrhal enteritis. - Other findings:
- - Organ weights: nda
- Histopathology: Observations include:
Hydrops ascites; focal fibrocaseous peritonitis with deformation of the abdominal organs; thickening of the cutaneous gastric mucosa; hyperemia and hemorrhagic erosion of the glands in the gastric mucosa; catarrhal enteritis.
- Potential target organs: Body orifices, intestine, stomach, lungs, abdominal cavity, mesenteric vessels and liver.
Any other information on results incl. tables
The body regions, orifices, cavities and organs listed below were investigated by means of inspection and/or palpation with the use of appropriate tools (e.g. magnifying glass, stereo microscope, instruments) in order to determine the nutritional state and indicators of death in all animals.
1. |
Pelage |
21. |
Spleen |
2. |
Skin |
22. |
Kidneys |
3. |
Eye and eyelid conjunctiva |
23. |
Urinary bladder |
4. |
Nose |
24. |
Seminal vesicle |
5. |
Mouth |
25. |
Prostate |
6. |
Ear |
26. |
Testicles |
7. |
Anus |
27. |
Epididymis |
8. |
Preputial opening |
28. |
Ovaries |
9. |
Vulva |
29. |
Uterus |
10. |
Subcutaneous connective tissue |
30. |
Vagina* |
11. |
Abdominal cavity |
31. |
Thoracic cavity |
12. |
Pelvic cavity |
32. |
Pleura |
13. |
Peritoneum |
33. |
Heart |
14. |
Esophagus* |
34. |
Lungs |
15. |
Stomach |
35. |
Trachea |
16. |
Small intestine |
36. |
Thymus |
17. |
Large intestine |
37. |
Cerebrum* |
18. |
Mesenteric lymph nodes |
38. |
Middle ear |
19. |
Liver |
39. |
Application point |
20. |
Pancreas |
|
|
* Only with pathological findings that are suspicious due to the toxicity profile or other special pathological/anatomical findings.
Only pathological/anatomical findings were noted. Consideration was given to localization, size or number, colour, surface, cross-section, consistency and/or correlation between the diagnoses of all the animals, separated by dose group.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not specified
- Remarks:
- Criteria used for interpretation of results: not specified
- Conclusions:
- DL50, oral in rats for this study is 219 mg/kg (probit analysis).
- Executive summary:
In the Systemic Test of Rat Tolerance to a Single Oral Dose (DL50) (Schering AG Prot No.: 925), the test material was found to have an DL50 of 219 mg/kg with confidence limits of 157 - 277 mg/kg.
From dosages of 200 mg and up, apathy, dyspnoea, diarrhea were observed. The animals that died, died 2 - 13 days after application.
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