Registration Dossier
Registration Dossier
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EC number: 204-116-4 | CAS number: 115-95-7
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Based on a measured log Pow of 3.9 the BCF of linalyl actetate was calculated to be 174 L/kg ww.
Key value for chemical safety assessment
- BCF (aquatic species):
- 174 L/kg ww
Additional information
QSAR Disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of linalyl acetate (Q)SAR results were used for bioaccumulation. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore and for reasons of animal welfare,further experimental studies on bioaccumulation are not provided.
Results
The bioaccumulative potential of linalyl acetate was estimated by a scientifically accepted calculation method using BCFBAF v3.01 (EpiSuite v.411). The BCF was calculated to be 174 L/kg ww.
Based on a calculated BCF of 174 L/kg ww and a measured log Pow of 3.9 moderate accumulation of the substance in organisms is possible. However, the substance is not stable in water and hydrolyses very rapidly to linalool and acetic acid. The product of hydrolysis, linalool (CAS 78-70-6) has a log Pow of 2.7 indicating a low accumulation potential. The bioaccumulation potential of linalyl acetate is therefore expected to be low under environmental conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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