Registration Dossier
Registration Dossier
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EC number: 202-429-0 | CAS number: 95-53-4
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature
Data source
Reference
- Title:
- No information
- Author:
- Morigami S, Nisimura I (1940) Experimental studies on aniline bladder tumors. Gann Jpn J Cancer Res 34, 146-147; cited Toxikolog.-arbeitsmed. Begruendung von MAK-Werten, VCH|(1986)
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- o-toluidine
- EC Number:
- 202-429-0
- EC Name:
- o-toluidine
- Cas Number:
- 95-53-4
- Molecular formula:
- C7H9N
- IUPAC Name:
- 2-methylaniline
- Details on test material:
- IUCLID4 Test substance: other TS: o-toluidine, no data on purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- every second day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5 % solution in chloroform
Basis:
- Control animals:
- other: no data specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
In the advanced stages (time not specified) massive bladder haemorrhage was found together with vacuolization of the bladder epithelial cells. In many cases there was papilliferous proliferation of the epithelial cells into the lumen.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
