Registration Dossier
Registration Dossier
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EC number: 203-825-6 | CAS number: 111-01-3
Long-term toxicity to fish
Administrative data
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Kindly find QMRF and QRPF enclosed
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- Version / remarks:
- ECHA guidance on QSAR R6
- GLP compliance:
- no
- Remarks:
- not relevant for QSAR
Test material
- Reference substance name:
- 2,6,10,15,19,23-hexamethyltetracosane
- EC Number:
- 203-825-6
- EC Name:
- 2,6,10,15,19,23-hexamethyltetracosane
- Cas Number:
- 111-01-3
- Molecular formula:
- C30H62
- IUPAC Name:
- 2,6,10,15,19,23-hexamethyltetracosane
- Test material form:
- other: liquid
- Details on test material:
- Synthetic squalane
Constituent 1
Results and discussion
Effect concentrations
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Remarks on result:
- other: NOEC > water solubility limit
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item falls within the domain of the model except for the descriptor domain where it falls beyond the limit where the toxicity value is predicted as greater than the water solubility value within the exposure period of the test. This results is supported by the fact than the substance can be considered as highly insoluble. Therefore, this endpoint result can be considered valid for use in risk assessment and classification and labelling.
The 28d-NOEC of the test item to fish was predicted as greater than the subcooled liquid water solubility value within the exposure period of the test.
95% confidence interval (α = 0.05): not determined - Executive summary:
QSAR prediction adapted to OECD 210 test method
The test item falls within the domain of the model except for the descriptor domain where it falls beyond the limit where the toxicity value is predicted as greater than the water solubility value within the exposure period of the test. This results is supported by the fact than the substance can be considered as highly insoluble. Therefore, this endpoint result can be considered valid for use in risk assessment and classification and labelling.
The 28d-NOEC of the test item to fish was predicted as greater than the subcooled liquid water solubility value within the exposure period of the test.
95% confidence interval (α = 0.05): not determined
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