Registration Dossier
Registration Dossier
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EC number: 216-643-7 | CAS number: 1633-05-2
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 55992-1:2006 (Determination of a parameter for the dust formation of pigments and extenders – Part 1: Rotation method)
- Principles of method if other than guideline:
- The Heubach dust meter is modified in a way that a seven stage cascade impactor is connected to the system. This involves an additional air fed of 20 L/min via the coarse dust separator needed to supply the cascade impactor with 40 L/min air current as specified in the manufacturer’s specificcations.
The calculation report: Grewe, T (2010)
The Multiple-Path Particle Dosimetry Model (MPPD, v2.0; CIIT, 2006) was used to predict this fractional deposition behaviour for workers.
The model algorithms calculate the deposition (and clearance) of mono-disperse and polydisperse aerosols in the respiratory tract for particles ranging from ultra-fine (0.01 microns) to coarse (20 microns) sizes. Within each airway, deposition is calculated using theoretically derived efficiencies for deposition by diffusion, sedimentation and impaction within the airway or airway bifurcation. Filtration of aerosols by the head is determined using empirical efficiency functions (for further information see "attached background material"). - GLP compliance:
- no
- Type of method:
- rotating drum method
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- Strontium carbonate
- EC Number:
- 216-643-7
- EC Name:
- Strontium carbonate
- Cas Number:
- 1633-05-2
- Molecular formula:
- CH2O3.Sr
- IUPAC Name:
- strontium carbonate
- Details on test material:
- - Name of test material (as cited in study report): Strontium carbonate
- Molecular formula (if other than submission substance): SrCO3
- Molecular weight (if other than submission substance): 147.6 g/mol
- Physical state: solid, odourless white powder
No further information on test materail was stated
Constituent 1
Results and discussion
Particle size
- Percentile:
- D50
- Remarks on result:
- other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
Any other information on results incl. tables
Dustiness (airborne fraction): total: 6.52 mg/g.
In the original study report by DMT, a calculation of the mass median diameter was not conducted. Since the deposited fractions were provided for each of the cascade impactor stages, it was possible to fit a bi-modal lognormal distribution to the data by standard non-linear regression procedure. As a result, the MMAD and GSD are calculable and reported (p1: 35.7%, MMAD1 = 4.02 µm, GSD1 = 1.82, p2: 64.3%, MMAD2 = 34.20µm, GSD2 = 2.02). As the cascade impactor already takes aerodynamic characteristics of the particles into account, the reported mass median diameter can be interpreted as the mass medianaerodynamicdiameter.
This figure and the corresponding GSD were used as distribution parameters for the MPPD model enabling an estimation of deposited dust fractions in the human respiratory tract: These fractions were estimated as follows:
Head (ET): 55.62%
Tracheobronchial (TB): 0.95%
Pulmonary (PU): 2.58%
Applicant's summary and conclusion
- Conclusions:
- Strontium carbonate
Total Dustiness (airborne fraction): 6.52 mg/g (experimental result, DMT Report).
Mass median aerodynamic diamaters (bi-modal distribution) of airborne fraction: MMAD1 = 4.01 µm (35.7%) , MMAD2 = 34.20 µm (64.3%) (distribution fitted to cascade impactor data, percentale in parentheses indicates weighting factor).
Geometric standard deviation of MMAD: GSD1 = 1.82, GSD 2 = 2.02
Fractional deposition in human respiratory tract (MPPD model, based on calculated MMAD):
Head (ET): 55.62%
Tracheobronchial (TB): 0.95%
Pulmonary (PU): 2.58%
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