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Diss Factsheets
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EC number: 225-768-6 | CAS number: 5064-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
The physico-chemical data indicate that the substance is not bioaccumulative (Log Kow = -13.2 at pH7) and is readily biodegradable, it is very unlikely that the substance will biomagnify through the food chain resulting in exposure to birds. Secondary poisoning is not expected and for this reason the need for bird toxicity studies is waived.
Key value for chemical safety assessment
Additional information
In Annex X of Regulation (EC) No 1907/2006, it is stated that long-term toxicity to terrestrial organisms, including birds, shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects of the substance and/or relevant degradation products on terrestrial organisms. Column 2 of Annex X states that studies do not need to be conducted if direct and indirect exposure of the soil compartment is unlikely. There are no ecotoxicity studies for birds relating to trisodium nitrilotriacetate (Na3NTA) and the requirement for terrestrial data is waived based on the low adsorption, low bioaccumulation potential, very low toxicity to aquatic organisms (extrapolated to terrestrial organisms), ready biodegradability and unlikely exposure to Na3NTA in soil.
Adsorption
It is not expected thatNa3NTA will adsorb onto the organic fraction of soils, sediments or suspended solids, due to the ionic structure of the substance though interaction with the mineral phase may occur. This assumption is supported by the studies conducted by Dunlapet al.,(1971) and Boltonet al.,(1993) who demonstrated that Na3NTA is neither strongly adsorbed by loam, clay-loam and sandy soils or marine surface sediments (Kp sediment-water = 1.6 L/kg). In addition, Na3NTA is a highly water-soluble organic substance with an aqueous solubility of 457 g/L.
Bioaccumulation
The partitioning behaviour of Na3NTA was estimated using the speciation model ChemEQL based on the assumption that Na3NTA completely dissociates upon dissolution in water and that the presence of the sodium ions does not appreciably influence the equilibrium behaviour of NTA. It was determined that the partitioning behaviour of Na3NTA is pH-dependent and the estimated Log Kow for the different NTA species is highest at pH 1.4, with a value of -4.14; at pH 7, the log Kow reduces to -13.2. At pH 14, the estimated log Kow is -31.2. The substance’s high hydrophilicity is demonstrated by the very low log octanol-water partition coefficient (Log Kow) of -13.2 at a neutral pH. These low distribution coefficients and Log Kow indicate the substance has a low adsorptive and bioaccumulative potential.
Biodegradability
Evidence for ready and inherent biodegradability is also provided; reliable tests resulted in 75 -100 % degradation after lag phases ranging between 1 and 16 days and the substance is regarded as readily biodegradable. The Canadian Ministry of the Environment (CCME, 2010) provides additional evidence of the rapid degradation of NTA and products where it was reported that NTA is readily biodegraded in all environmental compartments even at low environmental temperatures. Therefore, biodegradation can be considered to be an important removal process of NTA in soil, sediment, surface water, and water treatment plants.
Toxicity
Furthermore, it is reasonable to assume that trends seen in aquatic toxicity are likely to be observed in terrestrial organisms. Reliable toxicity data are available for freshwater species representing fish, invertebrates and a mollusc. Short-term (acute) exposures of Na3NTA to fish ranged from 103 to 125 mg/L and invertebrate data ranged from 80 to 115 mg/L. All trophic levels of aquatic organisms revealed similar sensitivities to Na3NTA. Long-term exposures to invertebrates and fish were reported as NOECs of 9.3 and >54 mg/L, respectively. These short- and long-term data, when considered with bioaccumulative and degradation information, result in Na3NTA being non-classified and considered to be practically non-toxic to aquatic organisms. It is reasonable to assume that Na3NTA will also be non-toxic to soil organisms.
Exposure
There are no identified uses of the substance which involve direct application to soil. The CSR uses default environmental release fractions in accordance with technical guidance for CSR preparation. Release of the substance to soil as a result of application of Na3NTA in any of the identified uses is not intentional; the fraction release to soil is therefore a worst case scenario and can be considered very conservative. Moreover, due to the high solubility, ready biodegradability and low octanol-water partition coefficient of Na3NTA, this substance will not sorb to or persist in aerobic soils when used as directed under environmental conditions. The environmental concentrations of Na3NTA in soil predicted by EUSES2.1 may therefore be considered conservative because (i) default release factors to soil are higher than expected for identified uses and (ii) environmental fate and partitioning will tend to over-predict concentration in soil.
The regional and highest local PEC for soil are 0.000474 mg.kg dw-1(industrial) and 0.06 mg/kg wwt-1(manufacture), respectively. Accordingly, exposure to soils, as predicted by EUSES with conservative release and distribution assumptions, is considered de minimis, and no further data is required.
In summary, based on the evidence of low adsorption, low bioaccumulative potential, very low toxicity to aquatic organisms (extrapolated to terrestrial organisms), ready biodegradability and no potential for exposure, the requirement for avian data is waived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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