Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-073-9 | CAS number: 20837-86-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study was preformed according to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 431 Determination "In vitro Skin Corrosion: Human Skin Model Test"
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Lead cyanamidate
- EC Number:
- 244-073-9
- EC Name:
- Lead cyanamidate
- Cas Number:
- 20837-86-9
- Molecular formula:
- CN2.Pb
- IUPAC Name:
- λ²-lead(2+) (azanidylenemethylidene)azanide
Constituent 1
Test animals
- Species:
- other: Human Skin Model EpiDerm TM
- Strain:
- other: normal , human derived epidermal keratinocytes
Test system
- Type of coverage:
- other: Human Skin Model EpiDerm TM
- Preparation of test site:
- other: Human Skin Model EpiDerm TM
- Vehicle:
- water
- Controls:
- other: Human Skin Model EpiDerm TM
- Duration of treatment / exposure:
- 3 min and 1 h
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: other: Human Skin Model EpiDerm TM
- Value:
- > 1.75 - < 1.76
- Remarks on result:
- other:
- Remarks:
- Basis: other: Human Skin Model EpiDerm TM. Time point: 3 min. Reversibility: no data. (migrated information)
- Irritation / corrosion parameter:
- other: other: Human Skin Model EpiDerm TM
- Value:
- > 1.66 - < 1.67
- Remarks on result:
- other:
- Remarks:
- Basis: other: Human Skin Model EpiDerm TM. Time point: 1h. (migrated information)
Any other information on results incl. tables
One valid experiment was performed.
Two tissues of the human skin model EpiDermTMwere treated with Cyanamide, lead(2+) salt (1:1)
for three minutes and one hour, respectively.25 mg of the solid test item were applied to each tissue and spread to match the tissue size.
Deionised water was used as negative control, 8m KOH was used as positive control.
After treatment with the negative control the absorbance values were well above the required acceptability criterion of mean OD > 0.8 for both treatment intervals thus showing the quality of the tissues. The positive control showed clear corrosive effects for both treatment intervals.
After three minutes treatment with the test item, the relative absorbance values were reduced to 97.6 %. This value is well above the threshold for corrosion potential (50%). After one hour treatment, relative absorbance values were reduced to 95.0 %. This value, too, is well above the threshold for corrosion potential (15%).
Therefore, Cyanamide, lead(2+) salt (1:1)
considered as not corrosive in the Human Skin Model Test.Applicant's summary and conclusion
- Interpretation of results:
- other: not corrosive
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The presented data are reliable and adequate.
- Executive summary:
The test item is considered not corrosive.
After three minutes treatment, the relative absorbance values were decreased to 97.6%. This value is well above the threshold for corrosivity (50%). After one hour treatment relative absorbance values were reduced to 95.0%. This value is well above the threshold for corrosivity (15%).
The values of the negative control were well above the required acceptability criterion of mean OD>0.8 for both treatment interval thus showing the quality of the tissues.
The value of the positive control induced a decrease in the relative absorbance as compared to the negative control to 28.2% for the three minutes treatment interval and 12.2% for the one hour treatment interval thus ensuring the validity of the test system.
For these reasons, the result of the test is considered valid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.