Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-699-5 | CAS number: 124-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Well documented report, details missing
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- The test substance (ca. 0.5 g of the 80% suspension in water) was applied to a 2.5 x 2.5 cm application site of white Vienna rabbits for 3 min under occlusive conditions. The skin was left intact. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 24, 48 hours and at the end of the observation period. Findings were graded as described in OECD test guideline 404.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium methanolate
- EC Number:
- 204-699-5
- EC Name:
- Sodium methanolate
- Cas Number:
- 124-41-4
- Molecular formula:
- CH4O.Na
- IUPAC Name:
- sodium methanolate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler
- Weight at study initiation: 2.91 and 3.0 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- other: untreated skin of the same animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): ca. 0.5 g
- Concentration (if solution): 80% - Duration of treatment / exposure:
- 3 minutes
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- no information given
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: 1 animal of 2
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other:
- Remarks:
- extended patchy necrosis (not specified if animal 1 or 2), which led to full thickness necrosis of the skin (day 8)
- Irritation parameter:
- erythema score
- Basis:
- other: 1 animal of 2
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other:
- Remarks:
- patchy necrosis (not specified if animal 1 or 2), which led to full thickness necrosis of the skin (day 8)
- Irritation parameter:
- edema score
- Basis:
- other: 1 animal of 2
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other:
- Remarks:
- extended in 1 animal (not specified if animal 1 or 2)
- Irritation parameter:
- edema score
- Basis:
- other: 1 animal of 2
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 day
- Remarks on result:
- other:
- Remarks:
- extended in 1 animal (not specified if animal 1 or 2)
- Irritation parameter:
- erythema score
- Basis:
- other: 1 animal of 2
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: extended patchy necrosis (not specified if animal 1 or 2), which led to full thickness necrosis of the skin (day 8)
- Irritation parameter:
- erythema score
- Basis:
- other: 1 animal of 2
- Time point:
- 48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: very severe necrosis (parchement-like; not specified if animal 1 or 2), which led to full thickness necrosis of the skin (day 8).
- Irritation parameter:
- edema score
- Basis:
- animal: 1 animal of 2
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: extended in 1 animal (not specified if animal 1 or 2)
- Irritation parameter:
- edema score
- Basis:
- other: 1 animal of 2
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: extended in 1 animal (not specified if animal 1 or 2)
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- not determinable
- Remarks:
- score not provided due to sever necrosis
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- not determinable
- Remarks:
- score not provided due to severe necrosis
- Irritant / corrosive response data:
- - 3 min: Erythema: 2 (2/2 animals), Edema 0 (2/2 animals)
- 8 days: Erythema: 4 (Necrosis, leather-like, 2/2 animals), Edema: 1 (2/2 animals)
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive) based on GHS criteria
- Conclusions:
- The test material was found to be corrosive to rabbit skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.