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EC number: 200-898-6 | CAS number: 75-75-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study with acceptable restrictions (Not exposed until day prior to scheduled kill, no toxic effects of highest dose applied)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
- Reference Type:
- publication
- Title:
- HPVIS, IUCLID Data Set for Methanesulphonic acid, CAS no. 75-75-2
- Author:
- US-EPA
- Year:
- 2 003
- Bibliographic source:
- HPV Chemicals Challenge Program OPPT NCIC 201-14249B
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Deviations:
- yes
- Remarks:
- Not exposed until day prior to scheduled kill, no toxic effects of highest dose applied
- GLP compliance:
- yes
- Remarks:
- Wil Research Laboratories
Test material
- Reference substance name:
- Methanesulphonic acid
- EC Number:
- 200-898-6
- EC Name:
- Methanesulphonic acid
- Cas Number:
- 75-75-2
- Molecular formula:
- CH4O3S
- IUPAC Name:
- methanesulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): Methanesulfonic acid
- Physical state: clear colorless liquid
- Composition of test material, percentage of components: 70.15 % in water
- Lot/batch No.: C06G
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories (Portage, Michigan)
- Age at study initiation: approx. 81 days
- Weight at study initiation: 266±9.5 g
- Housing: single
- Diet (e.g. ad libitum): Certified Rodent Labdiet, PMI Feeds Inc.
- Water (e.g. ad libitum): drinking water
- Acclimation period: 11 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): ca. 22
- Humidity (%): 44.5-61.2
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- VEHICLE
- Vehicle: deionized water
- Concentration in vehicle: 25, 25 and 50 mg/ml for the 25, 100 and 400 mg/kg bw/day groups, respectively
- Amount of vehicle (if gavage): 1, 4 and 8 ml/kg bw for the 25, 100 and 400 mg/kg bw/day groups, respectively - Analytical verification of doses or concentrations:
- yes
- Details on mating procedure:
- - Impregnation procedure: cohoused (paired in the home cage of the male for mating)
- If cohoused:
- M/F ratio per cage: paired (1/1)
- Proof of pregnancy: sperm in vaginal smear day 0 of pregnancy - Duration of treatment / exposure:
- GD 6 to 15
- Frequency of treatment:
- once daily
- Duration of test:
- up to GD 20
Doses / concentrations
- Remarks:
- Doses / Concentrations:
25, 100 and 400 mg/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- 25 females
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Dose selection rationale: Based on dose range-finding developmental toxicity study on Methane Sulfonic Acid (MSA) in rats. MSA was orally administered to 5 groups of 8 rats once daily for GD 6-15 at dosage levels of 25, 50, 100, 200 and 300 mg/kg bw/day. No mortalities were observed. All maternal animals survived to the scheduled necropsy on GD 20. Rales, laboured respiration and gasping; findings of red material around the nose and/or mouth in the 100, 200, and 300 mg/kg bw/day groups. Slight mean body weight losses (2 to 5 g) and reduction in food consumption occured in the 100, 200 and 300 mg/kg bw/day groups during gestation days 6 to 9 when evaluated on a group mean basis. Mean body weights, gravid uterine weights, net body weights and net body weight gains were unaffected by the treatment at all dose levels. No treatment-related internal findings were observed at necropsy at any dose level. No effects were observed at any dose level on intrauterine growth and survival. No external developmental variations or malformations were observed in any of the fetuses in the treated groups.
Examinations
- Maternal examinations:
- CLINICAL OBSERVATIONS: Yes
- Time schedule: twice a day, from day 0 through day 20
BODY WEIGHT: Yes
- Time schedule for examinations: on day 0, daily on day 6 to 16, and on day 20. Mean body weight changes were calculated for each corresponding interval and also for days 6-9, 9-12, 12-16, 6-16 and 0-20.
FOOD CONSUMPTION: Yes
- Time schedule: on day 0, daily on day 6 to 16, and on day 20
POST-MORTEM EXAMINATIONS: Yes
- Sacrifice on gestation day # 20
- Organs examined: Laparohysterectomy: uteri and ovaries, numbers of fetuses, early and late resorptions, total implantations and corpora lutea; mean gravid uterine weights and net body weight changes were calculated for each group; fetuses were weighed, sexed and examined for external, visceral and skeletal malformations and developmental variations. - Ovaries and uterine content:
- The ovaries and uterine content was examined after termination: Yes
Examinations included:
- Gravid uterus weight: Yes
- Number of corpora lutea: Yes
- Number of implantations: Yes
- Number of early resorptions: Yes
- Number of late resorptions: Yes
- Other: number of fetuses - Fetal examinations:
- - External examinations: Yes: [all per litter]
- Soft tissue examinations: Yes: [all per litter]
- Skeletal examinations: Yes: [all per litter]
- Head examinations: No data - Statistics:
- Chi-square test for fetal sex ratios; Fisher's Exact test for malformations and variations; Mann-whitney u-test for early and later resorptions, dead fetuses, postimplantation losses; One-way Anova with dunnett's test for maternal examinations and Kruskal-Wallis test for litter proportions of intrauterine data.
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:no effects
Details on maternal toxic effects:
Clinical observations: No clinical signs that could be attributed to the test substance were observed in the treated groups. No mortality was observed until day 20 (necropsy). Body weight and food consumption were not affected by the treatment.
Necropsy: No treatment related internal findings were observed at any dose level. Intrauterine growth and survival were unaffected by test substance administration at all dose levels.
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- >= 400 mg/kg bw/day
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Details on embryotoxic / teratogenic effects:
Fetal external, soft tissue and skeletal malformations were observed in 0(0), 2(2), 2(2) and 1(1) fetuses (litters) in the control, 25, 100, and 400 mg/kg bw/day groups, respectively, and were considered to be spontaneous in origin. The developmental variations observed in the treated groups occurred similarly in the control group and/or in a manner which was not dose-related.
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- >= 400 mg/kg bw/day
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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