Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-273-8 | CAS number: 56-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- June 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: other guideline: "Depressor Substances Test" USP XX (1980)
- Deviations:
- not specified
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- L-alanine
- EC Number:
- 200-273-8
- EC Name:
- L-alanine
- Cas Number:
- 56-41-7
- Molecular formula:
- C3H7NO2
- IUPAC Name:
- L-alanine
Constituent 1
Test animals
- Species:
- cat
- Strain:
- other: crossbreed
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: D.WENZEL, Detmold, Germany
- Age at study initiation: no data
- Weight at study initiation: male 3.3 kg, female 2.2 kg
- Fasting period before study: 16 hours
- Housing: individually in cages with 1 m² floor area
- Diet (e.g. ad libitum): 66% lean meat, 23% oat flakes, 11% cooked vegetables (own production); 50 g/kg bw /day for 1 h
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days acclimatisation period before study begin
ENVIRONMENTAL CONDITIONS
According to method
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- other: 0.9% solution of NaCl
- Doses:
- consecutive intravenous application of test substance in ascending doses of 10.0, 30.0 and 100.0 mg/kg bw, alternating to intravenous application of histamine-base 10 µg/kg bw
- No. of animals per sex per dose:
- 1
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 5 min
- Frequency of observations and weighing: observation of blood pressure just before application and observation of maximum value after application of test substance
- Necropsy of survivors performed: no data vailable
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: no data vailable
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- other: influence of L-alanine on histamine-like antihypertensive effect on narcotized cats
- Effect level:
- 10 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no influence on histamine-like antihypertensive effect; see: any other information in the result
- Sex:
- male/female
- Dose descriptor:
- other: influence of L-alanine on histamine-like antihypertensive effect on narcotized cats
- Effect level:
- 30 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no influence on histamine-like antihypertensive effect; see: any other information in the result
- Sex:
- male/female
- Dose descriptor:
- other: influence of L-alanine on histamine-like antihypertensive effect on narcotized cats
- Effect level:
- 100 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no influence on histamine-like antihypertensive effect; see: any other information in the result
- Mortality:
- No mortality occured during the observation period
- Clinical signs:
- No signs of toxicity were observed, neither at the male nor the female animals
- Body weight:
- no data available
- Gross pathology:
- no data available
Any other information on results incl. tables
L-alanine has no influence on histamine-like antihypertensive effect on cats.
No acute toxic effects were observed in intravenous application of L-alanine up to a maximum dose of 100 mg/kg bw.
Applicant's summary and conclusion
- Conclusions:
- No acute toxic effects were observed after intravenous application of L-alanine up to a maximum dose of 100 mg/kg bw in cats. This indicates a low systemic toxicity of L-alanine and is an additional justification for waiving of an acute dermal toxicity study as to Annex VIII REACH.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.