Dodecene, branched

Endpoint summary

Description of key information

LD50 oral > 2000 mg/kg (BASF AG, 1989)
LC50 inhalation > 3.9 mg/L (inhalation risk test, BASF AG, 1989)
LD50 dermal > 2000 mg/kg (read across to other hogher olefins, SIDS documents 2004 and 2007 on the higher olefin category)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Additional information

Acute oral toxicity:

The potential to induce acute toxicity following oral administration of the test substance was tested similar to OECD test guideline 401 (BASF AG, 1989). Five female and male rats treated by gavage with 2000 mg/kg isododecene using CMC as vehicle and analyzed for 14 days. All animals survived treatment and did not show any signs of clinical symptoms and pathological findings. Hence, the LD50 of isododecene is > 2000 mg/kg.

Acute inhalation toxicity:

The potential of the test substance to induce acute toxicity following inhalation was tested in three male and female rats in a non-GLP study similar to OECD test guideline 403 with the Inhalation Hazard test (BASF AG, 1989). Rats were exposed by head/nose-only exposure to a calculated vapor of 3.8 mg/L isododecene for 7 h. While none of the animals died following exposure or showed pathological findings, the following clinical symptoms were recorded during exposure: accelerated breathing during the entire time of exposure, eyelid closure and attempts to escape during the first minute of exposure. Once exposure has been finished, no further clinical symptoms were monitored. 

Acute dermal toxicity:

A study with isododecene to analyze its acute dermal toxicity is not available. However, the potential to induce dermal toxicity has been analyzed in two structural analogues, (alkenes C11-C13, C12, CAS 68526-58-9 and 1-dodecene CAS 112-41-4) and are described in an OECD SIDS report (SIDS Initial Assessment Report for SIAM19, Higher olefins category, 2004) . While no mortality was observed in all rabbits treated up to 2446.0 mg/kg of alkenes C11 -C13, C12, one out of the four rabbits dies on the 7th day of observation following treatment with 1 -dodecene. Based on this weight of evidence approach, higher order olefins including isododecene are not expected to induce acute dermal toxicity (LD50 > 2000 mg/kg).

Justification for classification or non-classification

Isododecene does not warrant classification for acute toxicity according to Directive 67/548/EEC (DSD) and EC1272/2008 (CLP).

Isododecene belongs to the category of hydrocarbons and exhibits a kinemiatic viscosity below 20.5 mm2/s. Hence, the test substance is classified with Xn/R65 and Danger/H304 according to Directive 67/548/EEC (DSD) and EC1272/2008 (CLP), respectively.