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EC number: 700-102-1 | CAS number: 105112-76-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was designed to meet the requirements of OECD Guideline for Testing of Chemicals No. 402 "Acute Dermal Toxicity", Adopeted: 24 February 1987, and EU Methods for the determination of toxicity, Annex to Directive 92/69/EEC, Part B, Method B.3 Acute toxicity (dermal) and was performed without any deviation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The Department of Health of the Government of the United Kingdom
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-{[4'-(3-aminophenoxy)-[1,1'-biphenyl]-4-yl]oxy}aniline
- EC Number:
- 700-102-1
- Cas Number:
- 105112-76-3
- Molecular formula:
- C24H20N2O2
- IUPAC Name:
- 3-{[4'-(3-aminophenoxy)-[1,1'-biphenyl]-4-yl]oxy}aniline
- Details on test material:
- - Name of test material (as cited in study report): 3,3-(4,4-biphenylenedioxy)dianiline
- Substance type: Raw material for polymer
- Physical state: Off white powder
- Analytical purity: >99 %
- Lot/batch No.: 20070501
- Expiration date of the lot/batch: 30 April 2008
- Storage condition of test material: Room temperature
- Other: date of receipt 28 August 2007, supplied by Mitsui Chemicals Inc.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD 'SD'
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd, Margate, Kent, England
- Age at study initiation:
- Weight at study initiation: 246 to 381 g
- Fasting period before study:
- Housing: Animals were housed individually from Day 1 until Day 7 when they were returned to cages with five rats of the same sex. Cages were solid bottomed polycarbonate cages with stainless steel mesh lids. Each cage contained a quantity of autoclaved wood flake bedding. Cages, food hoppers, water bottles and bedding were changed at appropriate intervals.
- Diet (e.g. ad libitum): free access to a standard rodend diet (Rat and Mouse No. 1 Maintenance Diet)
- Water (e.g. ad libitum): free access to potable water from the public supply via polycarbonate bottles fitted with sipper tubes
- Acclimation period: 9 days prior to the begin of the study
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 to 23
- Humidity (%): 40 to 70
- Air changes (per hr): not available
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To:
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: 1 % w/v methylcellulose
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 50 mm x 50 mm
- % coverage: 100
- Type of wrap if used:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): warm water (30-40 °C)
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.99 mL/kg bodyweight
- Concentration (if solution): 666.7 mg/mL
VEHICLE
- Concentration (if solution): 1 % w/v aqueous methylcellulose - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bodyweight
- No. of animals per sex per dose:
- Five males and five females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed soon after dosing and at frequent intervals for the remainder of Day 1. On subsquent days, animals were observed once in the morning and again at the end of the experimental day (with the exception of Day 15 - morning only).
- Necropsy of survivors performed: yes. All animals were subjected to a macroscopic examination which consisted of opening the cranial, thoraic and abdominal cavities.
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- There were no deaths and no systemic response to treatment in any animal.
- Clinical signs:
- other: Very slight to well defined erythema was seen in three males and one female with very slight oedema observed in one male. These reactions had resolved by Day 5. In addition, scabbing confined to a small area of the dose site was noted for one male and one
- Gross pathology:
- No abnormalities were noted in any animal at the macroscopic examination at study termination on Day 15.
Any other information on results incl. tables
Table 1: Dermal reactions
Dose (mg/kg) |
Sex |
Animal no. |
E=Erythema O=Oedema |
Day |
||||
2 |
3 |
4 |
5-6 |
7-15 |
||||
2000 |
Male |
B1 |
E |
2 |
0 |
0 |
0 |
0 |
2000 |
Male |
O |
1 |
0 |
0 |
0 |
0 |
|
2000 |
Male |
B2 |
E |
0 |
0 |
0 |
0 |
0 |
2000 |
Male |
O |
0 |
0 |
0 |
0 |
0 |
|
2000 |
Male |
B3 |
E |
2 |
1 |
0 |
0 |
0 |
2000 |
Male |
O |
0 |
0 |
0e |
0e |
0 |
|
2000 |
Male |
B4 |
E |
2 |
1 |
0 |
0 |
0 |
2000 |
Male |
O |
0 |
0 |
0 |
0 |
0 |
|
2000 |
Male |
B5 |
E |
0 |
0 |
0 |
0 |
0 |
2000 |
Male |
O |
0 |
0 |
0 |
0 |
0 |
|
2000 |
Female |
B6 |
E |
0 |
0 |
0 |
0 |
0 |
2000 |
Female |
O |
0 |
0 |
0 |
0 |
0 |
|
2000 |
Female |
B7 |
E |
0 |
0 |
0 |
0 |
0 |
2000 |
Female |
O |
0 |
0 |
0 |
0 |
0 |
|
2000 |
Female |
B8 |
E |
0 |
0 |
0 |
0 |
0 |
2000 |
Female |
O |
0 |
0 |
0 |
0 |
0 |
|
2000 |
Female |
B9 |
E |
0 |
0 |
0 |
0 |
0 |
2000 |
Female |
O |
0 |
0 |
0 |
0 |
0 |
|
2000 |
Female |
B10 |
E |
1 |
1 |
1 |
0 |
0 |
2000 |
Female |
O |
0 |
0 |
0e |
0e |
0 |
e: Eschar/Scabbing (several small scabs on dose site)
Table 2: Individual bodyweights (g)
Dose (mg/kg) |
Sex |
Animal Number |
Bodyweight (g) at Day |
||
1* |
8 |
15 |
|||
2000 |
Male |
B1 |
381 |
408 |
463 |
2000 |
Male |
B2 |
348 |
382 |
422 |
2000 |
Male |
B3 |
364 |
383 |
443 |
2000 |
Male |
B4 |
362 |
389 |
436 |
2000 |
Male |
B5 |
374 |
410 |
454 |
2000 |
Female |
B6 |
273 |
279 |
308 |
2000 |
Female |
B7 |
254 |
254 |
272 |
2000 |
Female |
B8 |
259 |
259 |
282 |
2000 |
Female |
B9 |
246 |
254 |
281 |
2000 |
Female |
B10 |
253 |
272 |
302 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- The acute median lethal dermal dose (LD50) to rats was demonstrated to be greater than 2000 mg/kg bodyweight.
- Executive summary:
The acute dermal toxicity of 3,3-(4,4-biphenylenedioxy)dianiline (a raw material for polymer), to the rat, was studied according to OECD Guideline for Testing of Chemicals No. 402 "Acute Dermal Toxicity".
A group of ten Crl:CD rats (five males and five females) received a single topical application of the test substance, formulated at a maximum practical concentration in 1% w/v aqueous methylcellulose, at a dosage of 2000 mg/kg body weight, for 24 hours. All animals were killed as scheduled and examined macroscopically on Day 15, the end of the observation period. There were no deaths and no systemic response to treatment in any animal. Very slight to well defined erythema was seen in three males and one female with very slight oedema observed in one male. These reactions had resolved by Day 5. In addition, scabbing confined to a small area of the dose site was noted for one male and one female from Day 4 resolving completely by Day 7. One female made no body weight gain and three further females all made low bodyweight gains on Day 8, but all these bodyweight changes had recovered by Day15. All other animals were considered to have achieved satisfactory bodyweight gains throughout the study. No abnormalities were noted in any animal at the macroscopic examination at the study termination on Day 15. The acute median lethal dermal dose (LD50) to rats of 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline was demonstrated to be greater than 2000 mg/kg body weight
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